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Structures of Hsp90α and Hsp90ß bound to a purine-scaffold inhibitor reveal an exploitable residue for drug selectivity.
Huck, John D; Que, Nanette L S; Sharma, Sahil; Taldone, Tony; Chiosis, Gabriela; Gewirth, Daniel T.
Afiliação
  • Huck JD; Hauptman-Woodward Medical Research Institute, Buffalo, New York.
  • Que NLS; Department of Structural Biology, Jacobs School of Medicine & Biomedical Sciences, University at Buffalo, Buffalo, New York.
  • Sharma S; Hauptman-Woodward Medical Research Institute, Buffalo, New York.
  • Taldone T; Program in Chemical Biology and Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Chiosis G; Program in Chemical Biology and Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
  • Gewirth DT; Program in Chemical Biology and Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
Proteins ; 87(10): 869-877, 2019 10.
Article em En | MEDLINE | ID: mdl-31141217
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Purinas / Proteínas de Choque Térmico HSP90 / Descoberta de Drogas / Aminoácidos Limite: Humans Idioma: En Revista: Proteins Assunto da revista: BIOQUIMICA Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Purinas / Proteínas de Choque Térmico HSP90 / Descoberta de Drogas / Aminoácidos Limite: Humans Idioma: En Revista: Proteins Assunto da revista: BIOQUIMICA Ano de publicação: 2019 Tipo de documento: Article