Inward-facing conformation of a multidrug resistance MATE family transporter.

Zakrzewska, Sandra; Mehdipour, Ahmad Reza; Malviya, Viveka Nand; Nonaka, Tsuyoshi; Koepke, Juergen; Muenke, Cornelia; Hausner, Winfried; Hummer, Gerhard; Safarian, Schara; Michel, Hartmut

Zakrzewska, Sandra; Mehdipour, Ahmad Reza; Malviya, Viveka Nand; Nonaka, Tsuyoshi; Koepke, Juergen; Muenke, Cornelia; Hausner, Winfried; Hummer, Gerhard; Safarian, Schara; Michel, Hartmut.

Afiliação

Zakrzewska S; Department of Molecular Membrane Biology, Max Planck Institute of Biophysics, 60438 Frankfurt am Main, Germany.
Mehdipour AR; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, 60438 Frankfurt am Main, Germany.
Malviya VN; Department of Molecular Membrane Biology, Max Planck Institute of Biophysics, 60438 Frankfurt am Main, Germany.
Nonaka T; Department of Molecular Membrane Biology, Max Planck Institute of Biophysics, 60438 Frankfurt am Main, Germany.
Koepke J; Department of Molecular Membrane Biology, Max Planck Institute of Biophysics, 60438 Frankfurt am Main, Germany.
Muenke C; Department of Molecular Membrane Biology, Max Planck Institute of Biophysics, 60438 Frankfurt am Main, Germany.
Hausner W; Faculty of Microbiology, University of Regensburg, 93053 Regensburg, Germany.
Hummer G; Department of Theoretical Biophysics, Max Planck Institute of Biophysics, 60438 Frankfurt am Main, Germany.
Safarian S; Institute of Biophysics, Goethe University, 60438 Frankfurt am Main, Germany.
Michel H; Department of Molecular Membrane Biology, Max Planck Institute of Biophysics, 60438 Frankfurt am Main, Germany; schara.safarian@biophys.mpg.de hartmut.michel@biophys.mpg.de.

Proc Natl Acad Sci U S A ; 116(25): 12275-12284, 2019 06 18.

Article em En | MEDLINE | ID: mdl-31160466

Assuntos

Resistência a Múltiplos Medicamentos; Proteínas de Membrana Transportadoras/química; Conformação Proteica; Pyrococcus furiosus/metabolismo; Proteínas de Membrana Transportadoras/metabolismo; Pyrococcus furiosus/efeitos dos fármacos; Difração de Raios X

Palavras-chave

MATE transporter; inward-facing conformation; lipids; membrane protein structure; multidrug resistance

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Membrana Transportadoras / Conformação Proteica / Resistência a Múltiplos Medicamentos / Pyrococcus furiosus Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Alemanha

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