Disease activity in rheumatoid arthritis is inversely related to cerebral TSPO binding assessed by [<sup>11</sup>C]PBR28 positron emission tomography.

Forsberg, A; Lampa, J; Estelius, J; Cervenka, S; Farde, L; Halldin, C; Lekander, M; Olgart Höglund, C; Kosek, E

Disease activity in rheumatoid arthritis is inversely related to cerebral TSPO binding assessed by [¹¹C]PBR28 positron emission tomography.

Forsberg, A; Lampa, J; Estelius, J; Cervenka, S; Farde, L; Halldin, C; Lekander, M; Olgart Höglund, C; Kosek, E.

Afiliação

Forsberg A; Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet and Stockholm County Council, SE-171 76 Stockholm, Sweden. Electronic address: anton.forsberg@ki.se.
Lampa J; Department of Medicine, Rheumatology Unit, Center for Molecular Medicine (CMM), Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Estelius J; Department of Medicine, Rheumatology Unit, Center for Molecular Medicine (CMM), Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Cervenka S; Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet and Stockholm County Council, SE-171 76 Stockholm, Sweden.
Farde L; Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet and Stockholm County Council, SE-171 76 Stockholm, Sweden; PET Science Centre, Precision Medicine and Genomics, IMED Biotech Unit, AstraZeneca, Karolinska Institutet, Sweden.
Halldin C; Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet and Stockholm County Council, SE-171 76 Stockholm, Sweden.
Lekander M; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Stress Research Institute, Stockholm University, Stockholm, Sweden.
Olgart Höglund C; Department of Medicine and Center for Molecular Medicine (CMM), Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Kosek E; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

J Neuroimmunol ; 334: 577000, 2019 09 15.

Article em En | MEDLINE | ID: mdl-31260948

Assuntos

Acetamidas/metabolismo; Artrite Reumatoide/diagnóstico por imagem; Artrite Reumatoide/metabolismo; Radioisótopos de Carbono/metabolismo; Tomografia por Emissão de Pósitrons/métodos; Piridinas/metabolismo; Receptores de GABA/metabolismo; Adulto; Biomarcadores/metabolismo; Córtex Cerebral/diagnóstico por imagem; Córtex Cerebral/metabolismo; Progressão da Doença; Feminino; Humanos; Masculino; Pessoa de Meia-Idade; Ligação Proteica/fisiologia

Palavras-chave

Glia cell activation; Heart rate variability; Microglia; Pain; Positron emission tomography; Rheumatoid arthritis; TSPO; Vagus nerve

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Piridinas / Radioisótopos de Carbono / Receptores de GABA / Tomografia por Emissão de Pósitrons / Acetamidas Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Neuroimmunol Ano de publicação: 2019 Tipo de documento: Article

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