Kynurenine 3-Monooxygenase Inhibition during Acute Simian Immunodeficiency Virus Infection Lowers PD-1 Expression and Improves Post-Combination Antiretroviral Therapy CD4<sup>+</sup> T Cell Counts and Body Weight.

Swainson, Louise A; Ahn, Haelee; Pajanirassa, Priya; Khetarpal, Vinod; Deleage, Claire; Estes, Jacob D; Hunt, Peter W; Munoz-Sanjuan, Ignacio; McCune, Joseph M

Kynurenine 3-Monooxygenase Inhibition during Acute Simian Immunodeficiency Virus Infection Lowers PD-1 Expression and Improves Post-Combination Antiretroviral Therapy CD4⁺ T Cell Counts and Body Weight.

Swainson, Louise A; Ahn, Haelee; Pajanirassa, Priya; Khetarpal, Vinod; Deleage, Claire; Estes, Jacob D; Hunt, Peter W; Munoz-Sanjuan, Ignacio; McCune, Joseph M.

Afiliação

Swainson LA; Division of Experimental Medicine, University of California San Francisco, San Francisco, CA 94110; louise.swainson@ucsf.edu.
Ahn H; Division of Experimental Medicine, University of California San Francisco, San Francisco, CA 94110.
Pajanirassa P; Division of Experimental Medicine, University of California San Francisco, San Francisco, CA 94110.
Khetarpal V; CHDI Management/CHDI Foundation, Los Angeles, CA 90045; and.
Deleage C; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21701.
Estes JD; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21701.
Hunt PW; Division of Experimental Medicine, University of California San Francisco, San Francisco, CA 94110.
Munoz-Sanjuan I; CHDI Management/CHDI Foundation, Los Angeles, CA 90045; and.
McCune JM; Division of Experimental Medicine, University of California San Francisco, San Francisco, CA 94110.

J Immunol ; 203(4): 899-910, 2019 08 15.

Article em En | MEDLINE | ID: mdl-31285277

Assuntos

Linfócitos T CD4-Positivos/imunologia; Quinurenina 3-Mono-Oxigenase/antagonistas & inibidores; Receptor de Morte Celular Programada 1/biossíntese; Pirimidinas/farmacologia; Síndrome de Imunodeficiência Adquirida dos Símios/imunologia; Animais; Antirretrovirais/farmacologia; Peso Corporal/efeitos dos fármacos; Linfócitos T CD4-Positivos/efeitos dos fármacos; Inibidores Enzimáticos/farmacologia; Macaca mulatta; Receptor de Morte Celular Programada 1/efeitos dos fármacos; Síndrome de Imunodeficiência Adquirida dos Símios/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Linfócitos T CD4-Positivos / Síndrome de Imunodeficiência Adquirida dos Símios / Quinurenina 3-Mono-Oxigenase / Receptor de Morte Celular Programada 1 Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Immunol Ano de publicação: 2019 Tipo de documento: Article

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