Serine and one-carbon metabolism, a bridge that links mTOR signaling and DNA methylation in cancer.

Zeng, Ju-Deng; Wu, William K K; Wang, Hui-Yun; Li, Xiao-Xing

Zeng, Ju-Deng; Wu, William K K; Wang, Hui-Yun; Li, Xiao-Xing.

Afiliação

Zeng JD; State Key Laboratory of Oncology in South China, Collaborative Innovation center for Cancer Medicine, Sun Yat-sen University cancer center, Guangzhou, Guangdong, China; Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong, China.
Wu WKK; Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong, China; State Key Laboratory of Digestive diseases, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong, China.
Wang HY; State Key Laboratory of Oncology in South China, Collaborative Innovation center for Cancer Medicine, Sun Yat-sen University cancer center, Guangzhou, Guangdong, China. Electronic address: wanghy@sysucc.org.cn.
Li XX; State Key Laboratory of Oncology in South China, Collaborative Innovation center for Cancer Medicine, Sun Yat-sen University cancer center, Guangzhou, Guangdong, China. Electronic address: Lixiaox@sysucc.org.cn.

Pharmacol Res ; 149: 104352, 2019 11.

Article em En | MEDLINE | ID: mdl-31323332

Assuntos

Metilação de DNA; Neoplasias/genética; Serina/metabolismo; Transdução de Sinais; Serina-Treonina Quinases TOR/metabolismo; Animais; Epigênese Genética; Regulação Neoplásica da Expressão Gênica; Humanos; Neoplasias/metabolismo; Serina/genética; Serina-Treonina Quinases TOR/genética

Palavras-chave

5-Azacytidine (9444); Cancer therapy; DNA methylation; Decitabine (451668); Everolimus (6442177); Glutathione (124886); Methionine (PubChem CID 6137); One-carbon metabolism; Rapamycin (5284616); S-Adenosylmethionine (34755); Serine; Temsirolimus (6918289); Tetrahydrofolate (135444742); Tumorigenesis; Vitamin B12 (5311498); mTOR

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Serina / Transdução de Sinais / Metilação de DNA / Serina-Treonina Quinases TOR / Neoplasias Limite: Animals / Humans Idioma: En Revista: Pharmacol Res Assunto da revista: FARMACOLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China

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