Genetic determinants of VWF clearance and FVIII binding modify FVIII pharmacokinetics in pediatric hemophilia A patients.

Swystun, Laura L; Ogiwara, Kenichi; Rawley, Orla; Brown, Christine; Georgescu, Ilinca; Hopman, Wilma; Labarque, Veerle; Male, Christoph; Thom, Katharina; Blanchette, Victor S; Carcao, Manuel D; Lillicrap, David

Swystun, Laura L; Ogiwara, Kenichi; Rawley, Orla; Brown, Christine; Georgescu, Ilinca; Hopman, Wilma; Labarque, Veerle; Male, Christoph; Thom, Katharina; Blanchette, Victor S; Carcao, Manuel D; Lillicrap, David.

Afiliação

Swystun LL; Department of Pathology and Molecular Medicine and.
Ogiwara K; Department of Pathology and Molecular Medicine and.
Rawley O; Department of Pathology and Molecular Medicine and.
Brown C; Department of Pathology and Molecular Medicine and.
Georgescu I; Department of Pathology and Molecular Medicine and.
Hopman W; Department of Public Health Sciences, Queen's University, Kingston, ON, Canada.
Labarque V; Department of Pediatric Hemato-Oncology, University Hospitals Leuven, Leuven, Belgium.
Male C; Department of Pediatrics, Medical University of Vienna, Vienna, Austria; and.
Thom K; Department of Pediatrics, Medical University of Vienna, Vienna, Austria; and.
Blanchette VS; Department of Pediatrics, University of Toronto and Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON, Canada.
Carcao MD; Department of Pediatrics, University of Toronto and Division of Hematology/Oncology, Hospital for Sick Children, Toronto, ON, Canada.
Lillicrap D; Department of Pathology and Molecular Medicine and.

Blood ; 134(11): 880-891, 2019 09 12.

Article em En | MEDLINE | ID: mdl-31350267

Assuntos

Coagulação Sanguínea/genética; Fator VIII/farmacocinética; Hemofilia A/genética; Hemofilia A/metabolismo; Fator de von Willebrand/genética; Fator de von Willebrand/metabolismo; Adolescente; Testes de Coagulação Sanguínea; Criança; Fator VIII/uso terapêutico; Feminino; Variação Genética; Genótipo; Meia-Vida; Hemofilia A/sangue; Hemofilia A/tratamento farmacológico; Humanos; Masculino; Taxa de Depuração Metabólica/genética; Ligação Proteica; Proteólise

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Coagulação Sanguínea / Fator VIII / Fator de von Willebrand / Hemofilia A Tipo de estudo: Prognostic_studies Limite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: Blood Ano de publicação: 2019 Tipo de documento: Article

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