Frequent genetic aberrations in the cell cycle related genes in mucosal melanoma indicate the potential for targeted therapy.

Xu, Longwen; Cheng, Zhiyuan; Cui, Chuanliang; Wu, Xiaowen; Yu, Huan; Guo, Jun; Kong, Yan

Xu, Longwen; Cheng, Zhiyuan; Cui, Chuanliang; Wu, Xiaowen; Yu, Huan; Guo, Jun; Kong, Yan.

Afiliação

Xu L; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Renal Cancer and Melanoma, Peking University Cancer Hospital & Institute, 52 Fucheng Road, Beijing, 100142, China.
Cheng Z; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Renal Cancer and Melanoma, Peking University Cancer Hospital & Institute, 52 Fucheng Road, Beijing, 100142, China.
Cui C; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Renal Cancer and Melanoma, Peking University Cancer Hospital & Institute, 52 Fucheng Road, Beijing, 100142, China.
Wu X; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Renal Cancer and Melanoma, Peking University Cancer Hospital & Institute, 52 Fucheng Road, Beijing, 100142, China.
Yu H; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Renal Cancer and Melanoma, Peking University Cancer Hospital & Institute, 52 Fucheng Road, Beijing, 100142, China.
Guo J; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Renal Cancer and Melanoma, Peking University Cancer Hospital & Institute, 52 Fucheng Road, Beijing, 100142, China. guoj307@126.com.
Kong Y; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Renal Cancer and Melanoma, Peking University Cancer Hospital & Institute, 52 Fucheng Road, Beijing, 100142, China. k-yanbjcancer@163.com.

J Transl Med ; 17(1): 245, 2019 07 29.

Article em En | MEDLINE | ID: mdl-31358010

Assuntos

Proteínas de Ciclo Celular/genética; Variações do Número de Cópias de DNA/genética; Neoplasias de Cabeça e Pescoço/genética; Melanoma/genética; Mucosa/patologia; Animais; Biomarcadores Tumorais/genética; Ciclo Celular; Proliferação de Células; Ciclina D1/genética; Quinase 4 Dependente de Ciclina/genética; Inibidor p16 de Quinase Dependente de Ciclina/genética; Neoplasias Esofágicas/genética; Feminino; Dosagem de Genes; Variação Genética; Proteínas de Homeodomínio/genética; Humanos; Incidência; Camundongos; Camundongos Endogâmicos NOD; Camundongos SCID; Transplante de Neoplasias; Piperazinas/farmacologia; Piperidinas/farmacologia; Prognóstico; Pirazóis/farmacologia; Piridinas/farmacologia; Neoplasias Retais/genética; Análise de Sequência de RNA; Transdução de Sinais; Transativadores/genética; Neoplasias Urogenitais/genética

Palavras-chave

CCND1; CDK4; Mucosal melanoma; P16 INK4a; Targeted therapy

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas de Ciclo Celular / Variações do Número de Cópias de DNA / Neoplasias de Cabeça e Pescoço / Melanoma / Mucosa Tipo de estudo: Guideline / Incidence_studies / Prognostic_studies Limite: Animals / Female / Humans Idioma: En Revista: J Transl Med Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China

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