One-year results with selective bladder denervation in women with refractory overactive bladder.
Neurourol Urodyn
; 38(8): 2178-2184, 2019 11.
Article
em En
| MEDLINE
| ID: mdl-31359508
ABSTRACT
AIMS:
To report 1-year results with selective bladder denervation (SBD) of the trigone in women with refractory overactive bladder (OAB).METHODS:
In this prospective, international, multicenter case series, women with refractory OAB underwent a single SBD treatment of the bladder subtrigone region using temperature-controlled radiofrequency. Patients were followed for 1 year and evaluated for changes in OAB symptoms and adverse events.RESULTS:
Among 35 women, 29 (83%) returned for 1-year follow up. Median symptom reductions based on 3-day bladder diaries were 68% for urgency urinary incontinence ( P < .001), 67% for urinary incontinence ( P < .001), 43% for urgency episodes ( P < .001), 5% for urinary frequency ( P = .19), and 33% for the total urgency and frequency score ( P < .001), with the majority of treatment benefit realized in the first month. Treatment benefit was reported in 72% of patients, the clinical success rate (≥50% reduction in urgency urinary incontinence) was 69%, and the dry rate was 10%. Statistically significant improvements occurred on Symptom Bother and Health-related Quality of Life scales on the Overactive Bladder questionnaire, and on 6 of 9 King's Health Questionnaire domains. Patients with less severe baseline symptoms had similar quality of life improvements as those with more severe baseline symptoms. Device- or procedure-related adverse events were reported in 6 (17%) patients.CONCLUSIONS:
A single treatment with selective bladder denervation is durable for 1-year in a significant proportion of women with refractory overactive bladder.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Denervação
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Bexiga Urinária Hiperativa
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Incontinência Urinária de Urgência
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Ablação por Radiofrequência
Tipo de estudo:
Observational_studies
Limite:
Aged
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Female
/
Humans
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Middle aged
Idioma:
En
Revista:
Neurourol Urodyn
Ano de publicação:
2019
Tipo de documento:
Article