Host-directed therapies for parasitic diseases.
Future Med Chem
; 11(15): 1999-2018, 2019 08.
Article
em En
| MEDLINE
| ID: mdl-31390889
ABSTRACT
Parasitic infections are responsible for significant morbidity and mortality throughout the world. Management strategies rely primarily on antiparasitic drugs that have side effects and risk of drug resistance. Therefore, novel strategies are needed for treatment of parasitic infections. Host-directed therapy (HDT) is a viable alternative, which targets host pathways responsible for parasite invasion/survival/pathogenicity. Recent innovative combinations of genomics, proteomics and computational biology approaches have led to discovery of several host pathways that could be promising targets for HDT for treating parasitic infections. Herein, we review major advances in HDT for parasitic disease with regard to core regulatory pathways and their interactions.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Parasitárias
/
Anti-Infecciosos
Limite:
Humans
Idioma:
En
Revista:
Future Med Chem
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Estados Unidos