Wound Healing Effect of Lawsonia inermis.
Skin Pharmacol Physiol
; 32(6): 295-306, 2019.
Article
em En
| MEDLINE
| ID: mdl-31466077
ABSTRACT
BACKGROUND:
Lawsonia inermis-extracted oil is known for therapeutic properties, especially wound healing. This study assesses the potential of this oil for wound healing in a rat model.METHODOLOGY:
To assess the potential of L. inermis-extracted oil for wound healing, phytochemical, antibacterial, and antioxidant analyses were conducted. Uniform wound excision was induced on the dorsum of randomly selected rats divided into 3 groups cleaned and treated with saline solution (control), Cicaflora (reference), and L. inermisoil. Biopsies performed after healing were histologically assessed.CONCLUSIONS:
The quality and content of the fatty acids in the oil were determined. Results showed a high content of bioactive components inducing an efficient wound healing effect determined by an in vivo study. Histological and chromatic assessment findings revealed healing in the oil-treated group but not in the untreated group, a full reepithelialization with reappearance of skin appendages and well-organized collagen fibers without any inflammatory cells. This might be due to a synergistic effect of the phytoconstituents present in the oil.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cicatrização
/
Óleos de Plantas
/
Lawsonia (Planta)
/
Antibacterianos
/
Antioxidantes
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
Skin Pharmacol Physiol
Assunto da revista:
DERMATOLOGIA
/
FARMACOLOGIA
/
FISIOLOGIA
Ano de publicação:
2019
Tipo de documento:
Article