Wnt ligand and receptor patterning in the liver.
Curr Opin Cell Biol
; 62: 17-25, 2020 02.
Article
em En
| MEDLINE
| ID: mdl-31509785
ABSTRACT
In the liver, the tight spatiotemporal regulation of Wnt/ß-catenin signaling is required to establish and maintain a metabolic form of tissue polarity termed zonation. In this review, we discuss the latest technologies applied in the study of liver zonation and provide a summary of the Wnt ligand and receptor expression patterns in the hepatic lobule. We further discuss the mechanisms, by which Wnt instructive cues might be spatially confined and propagated along the central vein-portal triad axis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Expressão Gênica
/
Via de Sinalização Wnt
/
Fígado
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Cell Biol
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Reino Unido