Endothelial Cell Development and Its Application to Regenerative Medicine.
Circ Res
; 125(4): 489-501, 2019 08 02.
Article
em En
| MEDLINE
| ID: mdl-31518171
ABSTRACT
The formation and remodeling of a functional circulatory system is critical for sustaining prenatal and postnatal life. During embryogenesis, newly differentiated endothelial cells require further specification to create the unique features of distinct vessel subtypes needed to support tissue morphogenesis. In this review, we explore signaling pathways and transcriptional regulators that modulate endothelial cell differentiation and specification, as well as applications of these processes to stem cell biology and regenerative medicine. We also summarize recent technical advances, including the growing utilization of single-cell sequencing to study vascular heterogeneity and development.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Endotélio Vascular
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Neovascularização Fisiológica
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Medicina Regenerativa
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Células Progenitoras Endoteliais
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Circ Res
Ano de publicação:
2019
Tipo de documento:
Article