Risk factors of post-surgery complications in children with thyroid cancer.
Int J Pediatr Otorhinolaryngol
; 127: 109673, 2019 Dec.
Article
em En
| MEDLINE
| ID: mdl-31546062
ABSTRACT
INTRODUCTION:
Thyroid cancer in children is a hot topic because of the large clinical heterogeneity and the risk of severe complications. We aimed to study 1. The frequency, 2. Etiology, and 3. Risk factors of post-surgery complications of thyroid cancer. MATERIAL ANDMETHODS:
A retrospective analysis including risk factors for post-surgery complications of patients treated for thyroid malignancies in years 2006-2018 was performed.RESULTS:
Over a period of 12 years 22 patients with thyroid malignancy (68% female; 12.6⯱â¯4.0 years of age, median follow-up 6 years) were identified. Histologically, 12 (55%) patients had papillary carcinoma. Six patients (27.3%) had multiple endocrine neoplasia type 2 (MEN2) syndrome, 3 (13.7%) patients had medullary carcinoma and 1 patient had follicular carcinoma. Neck lymph node metastases were diagnosed in 8 (36.4%), distant metastases in 6 (27.3%), and both locations were involved in 4 (18.2%) patients. Six (27.3%) children had surgical complications 1 child had unilateral vocal cord paralysis and transient hypoparathyroidism and 5 had transient hypoparathyroidism. The higher risk of surgery complications in forward stepwise logistic regression was associated in with distant metastases (R2â¯=â¯0.584, OR 52.63, pâ¯=â¯0.010).CONCLUSIONS:
Postoperative complications were significantly associated with presence of distant metastases. Favorable results were observed in with children with MEN2 syndrome.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Complicações Pós-Operatórias
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Tireoidectomia
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Neoplasia Endócrina Múltipla
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Neoplasias da Glândula Tireoide
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Carcinoma Papilar
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Carcinoma Neuroendócrino
/
Adenocarcinoma Folicular
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
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Child
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Female
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Humans
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Male
Idioma:
En
Revista:
Int J Pediatr Otorhinolaryngol
Ano de publicação:
2019
Tipo de documento:
Article