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Community-wide Screening for Tuberculosis in a High-Prevalence Setting.
Marks, Guy B; Nguyen, Nhung V; Nguyen, Phuong T B; Nguyen, Thu-Anh; Nguyen, Hoa B; Tran, Khoa H; Nguyen, Son V; Luu, Khanh B; Tran, Duc T T; Vo, Qui T N; Le, Oanh T T; Nguyen, Yen H; Do, Vu Q; Mason, Paul H; Nguyen, Van-Anh T; Ho, Jennifer; Sintchenko, Vitali; Nguyen, Linh N; Britton, Warwick J; Fox, Greg J.
Afiliação
  • Marks GB; From the Woolcock Institute of Medical Research (G.B.M., P.T.B.N., T.-A.N., K.B.L., D.T.T.T., Q.T.N.V., O.T.T.L., Y.H.N., P.H.M., J.H., G.J.F.), the National Lung Hospital (N.V.N., H.B.N.), the National Institute of Hygiene and Epidemiology (V.-A.T.N..), and the National Tuberculosis Control Program
  • Nguyen NV; From the Woolcock Institute of Medical Research (G.B.M., P.T.B.N., T.-A.N., K.B.L., D.T.T.T., Q.T.N.V., O.T.T.L., Y.H.N., P.H.M., J.H., G.J.F.), the National Lung Hospital (N.V.N., H.B.N.), the National Institute of Hygiene and Epidemiology (V.-A.T.N..), and the National Tuberculosis Control Program
  • Nguyen PTB; From the Woolcock Institute of Medical Research (G.B.M., P.T.B.N., T.-A.N., K.B.L., D.T.T.T., Q.T.N.V., O.T.T.L., Y.H.N., P.H.M., J.H., G.J.F.), the National Lung Hospital (N.V.N., H.B.N.), the National Institute of Hygiene and Epidemiology (V.-A.T.N..), and the National Tuberculosis Control Program
  • Nguyen TA; From the Woolcock Institute of Medical Research (G.B.M., P.T.B.N., T.-A.N., K.B.L., D.T.T.T., Q.T.N.V., O.T.T.L., Y.H.N., P.H.M., J.H., G.J.F.), the National Lung Hospital (N.V.N., H.B.N.), the National Institute of Hygiene and Epidemiology (V.-A.T.N..), and the National Tuberculosis Control Program
  • Nguyen HB; From the Woolcock Institute of Medical Research (G.B.M., P.T.B.N., T.-A.N., K.B.L., D.T.T.T., Q.T.N.V., O.T.T.L., Y.H.N., P.H.M., J.H., G.J.F.), the National Lung Hospital (N.V.N., H.B.N.), the National Institute of Hygiene and Epidemiology (V.-A.T.N..), and the National Tuberculosis Control Program
  • Tran KH; From the Woolcock Institute of Medical Research (G.B.M., P.T.B.N., T.-A.N., K.B.L., D.T.T.T., Q.T.N.V., O.T.T.L., Y.H.N., P.H.M., J.H., G.J.F.), the National Lung Hospital (N.V.N., H.B.N.), the National Institute of Hygiene and Epidemiology (V.-A.T.N..), and the National Tuberculosis Control Program
  • Nguyen SV; From the Woolcock Institute of Medical Research (G.B.M., P.T.B.N., T.-A.N., K.B.L., D.T.T.T., Q.T.N.V., O.T.T.L., Y.H.N., P.H.M., J.H., G.J.F.), the National Lung Hospital (N.V.N., H.B.N.), the National Institute of Hygiene and Epidemiology (V.-A.T.N..), and the National Tuberculosis Control Program
  • Luu KB; From the Woolcock Institute of Medical Research (G.B.M., P.T.B.N., T.-A.N., K.B.L., D.T.T.T., Q.T.N.V., O.T.T.L., Y.H.N., P.H.M., J.H., G.J.F.), the National Lung Hospital (N.V.N., H.B.N.), the National Institute of Hygiene and Epidemiology (V.-A.T.N..), and the National Tuberculosis Control Program
  • Tran DTT; From the Woolcock Institute of Medical Research (G.B.M., P.T.B.N., T.-A.N., K.B.L., D.T.T.T., Q.T.N.V., O.T.T.L., Y.H.N., P.H.M., J.H., G.J.F.), the National Lung Hospital (N.V.N., H.B.N.), the National Institute of Hygiene and Epidemiology (V.-A.T.N..), and the National Tuberculosis Control Program
  • Vo QTN; From the Woolcock Institute of Medical Research (G.B.M., P.T.B.N., T.-A.N., K.B.L., D.T.T.T., Q.T.N.V., O.T.T.L., Y.H.N., P.H.M., J.H., G.J.F.), the National Lung Hospital (N.V.N., H.B.N.), the National Institute of Hygiene and Epidemiology (V.-A.T.N..), and the National Tuberculosis Control Program
  • Le OTT; From the Woolcock Institute of Medical Research (G.B.M., P.T.B.N., T.-A.N., K.B.L., D.T.T.T., Q.T.N.V., O.T.T.L., Y.H.N., P.H.M., J.H., G.J.F.), the National Lung Hospital (N.V.N., H.B.N.), the National Institute of Hygiene and Epidemiology (V.-A.T.N..), and the National Tuberculosis Control Program
  • Nguyen YH; From the Woolcock Institute of Medical Research (G.B.M., P.T.B.N., T.-A.N., K.B.L., D.T.T.T., Q.T.N.V., O.T.T.L., Y.H.N., P.H.M., J.H., G.J.F.), the National Lung Hospital (N.V.N., H.B.N.), the National Institute of Hygiene and Epidemiology (V.-A.T.N..), and the National Tuberculosis Control Program
  • Do VQ; From the Woolcock Institute of Medical Research (G.B.M., P.T.B.N., T.-A.N., K.B.L., D.T.T.T., Q.T.N.V., O.T.T.L., Y.H.N., P.H.M., J.H., G.J.F.), the National Lung Hospital (N.V.N., H.B.N.), the National Institute of Hygiene and Epidemiology (V.-A.T.N..), and the National Tuberculosis Control Program
  • Mason PH; From the Woolcock Institute of Medical Research (G.B.M., P.T.B.N., T.-A.N., K.B.L., D.T.T.T., Q.T.N.V., O.T.T.L., Y.H.N., P.H.M., J.H., G.J.F.), the National Lung Hospital (N.V.N., H.B.N.), the National Institute of Hygiene and Epidemiology (V.-A.T.N..), and the National Tuberculosis Control Program
  • Nguyen VT; From the Woolcock Institute of Medical Research (G.B.M., P.T.B.N., T.-A.N., K.B.L., D.T.T.T., Q.T.N.V., O.T.T.L., Y.H.N., P.H.M., J.H., G.J.F.), the National Lung Hospital (N.V.N., H.B.N.), the National Institute of Hygiene and Epidemiology (V.-A.T.N..), and the National Tuberculosis Control Program
  • Ho J; From the Woolcock Institute of Medical Research (G.B.M., P.T.B.N., T.-A.N., K.B.L., D.T.T.T., Q.T.N.V., O.T.T.L., Y.H.N., P.H.M., J.H., G.J.F.), the National Lung Hospital (N.V.N., H.B.N.), the National Institute of Hygiene and Epidemiology (V.-A.T.N..), and the National Tuberculosis Control Program
  • Sintchenko V; From the Woolcock Institute of Medical Research (G.B.M., P.T.B.N., T.-A.N., K.B.L., D.T.T.T., Q.T.N.V., O.T.T.L., Y.H.N., P.H.M., J.H., G.J.F.), the National Lung Hospital (N.V.N., H.B.N.), the National Institute of Hygiene and Epidemiology (V.-A.T.N..), and the National Tuberculosis Control Program
  • Nguyen LN; From the Woolcock Institute of Medical Research (G.B.M., P.T.B.N., T.-A.N., K.B.L., D.T.T.T., Q.T.N.V., O.T.T.L., Y.H.N., P.H.M., J.H., G.J.F.), the National Lung Hospital (N.V.N., H.B.N.), the National Institute of Hygiene and Epidemiology (V.-A.T.N..), and the National Tuberculosis Control Program
  • Britton WJ; From the Woolcock Institute of Medical Research (G.B.M., P.T.B.N., T.-A.N., K.B.L., D.T.T.T., Q.T.N.V., O.T.T.L., Y.H.N., P.H.M., J.H., G.J.F.), the National Lung Hospital (N.V.N., H.B.N.), the National Institute of Hygiene and Epidemiology (V.-A.T.N..), and the National Tuberculosis Control Program
  • Fox GJ; From the Woolcock Institute of Medical Research (G.B.M., P.T.B.N., T.-A.N., K.B.L., D.T.T.T., Q.T.N.V., O.T.T.L., Y.H.N., P.H.M., J.H., G.J.F.), the National Lung Hospital (N.V.N., H.B.N.), the National Institute of Hygiene and Epidemiology (V.-A.T.N..), and the National Tuberculosis Control Program
N Engl J Med ; 381(14): 1347-1357, 2019 10 03.
Article em En | MEDLINE | ID: mdl-31577876
ABSTRACT

BACKGROUND:

The World Health Organization has set ambitious targets for the global elimination of tuberculosis. However, these targets will not be achieved at the current rate of progress.

METHODS:

We performed a cluster-randomized, controlled trial in Ca Mau Province, Vietnam, to evaluate the effectiveness of active community-wide screening, as compared with standard passive case detection alone, for reducing the prevalence of tuberculosis. Persons 15 years of age or older who resided in 60 intervention clusters (subcommunes) were screened for pulmonary tuberculosis, regardless of symptoms, annually for 3 years, beginning in 2014, by means of rapid nucleic acid amplification testing of spontaneously expectorated sputum samples. Active screening was not performed in the 60 control clusters in the first 3 years. The primary outcome, measured in the fourth year, was the prevalence of microbiologically confirmed pulmonary tuberculosis among persons 15 years of age or older. The secondary outcome was the prevalence of tuberculosis infection, as assessed by an interferon gamma release assay in the fourth year, among children born in 2012.

RESULTS:

In the fourth-year prevalence survey, we tested 42,150 participants in the intervention group and 41,680 participants in the control group. A total of 53 participants in the intervention group (126 per 100,000 population) and 94 participants in the control group (226 per 100,000) had pulmonary tuberculosis, as confirmed by a positive nucleic acid amplification test for Mycobacterium tuberculosis (prevalence ratio, 0.56; 95% confidence interval [CI], 0.40 to 0.78; P<0.001). The prevalence of tuberculosis infection in children born in 2012 was 3.3% in the intervention group and 2.6% in the control group (prevalence ratio, 1.29; 95% CI, 0.70 to 2.36; P = 0.42).

CONCLUSIONS:

Three years of community-wide screening in persons 15 years of age or older who resided in Ca Mau Province, Vietnam, resulted in a lower prevalence of pulmonary tuberculosis in the fourth year than standard passive case detection alone. (Funded by the Australian National Health and Medical Research Council; ACT3 Australian New Zealand Clinical Trials Registry number, ACTRN12614000372684.).
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose Pulmonar / Programas de Rastreamento / Doenças Endêmicas / Mycobacterium tuberculosis Tipo de estudo: Clinical_trials / Diagnostic_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Adolescent / Adult / Child / Female / Humans / Male País/Região como assunto: Asia Idioma: En Revista: N Engl J Med Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose Pulmonar / Programas de Rastreamento / Doenças Endêmicas / Mycobacterium tuberculosis Tipo de estudo: Clinical_trials / Diagnostic_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Adolescent / Adult / Child / Female / Humans / Male País/Região como assunto: Asia Idioma: En Revista: N Engl J Med Ano de publicação: 2019 Tipo de documento: Article