ALK-positive anaplastic large cell lymphoma of the thoracic spine occurring in pregnancy: A case report.

ABSTRACT

BACKGROUND: Anaplastic large cell lymphoma (ALCL) is a type of non-Hodgkin's lymphoma (NHL). ALCL is rare as a bone lesion and in pregnancy. CASE SUMMARY: We present the first case of anaplastic lymphoma kinase (ALK)+ ALCL of the thoracic spine during pregnancy. A 25-year-old pregnant woman was presented to us at 24 wk' gestation with severe back pain and weakness in the left lower limb. Imaging examination showed lesions at T10 and T11. She underwent posterior pedicle screw fixation and vertebroplasty. Pathological examination showed ALK+ ALCL. The patient chose to have therapeutic abortion after surgery and received chemotherapy in the hematology department. She now remains disease free with no neurological deficit after 30 mo' follow-up. CONCLUSION: ALK+ ALCL with the thoracic spine involvement is uncommon, especially in pregnancy. Many symptoms can be misunderstood during pregnancy; therefore, when a pregnant patient has persistent back pain or lower limb neurological symptoms, imaging examinations should be performed.