Systematic review and proposal of an in vivo reflectance confocal microscopy assessment tool for cutaneous lymphoma.
J Cutan Pathol
; 47(3): 295-304, 2020 Mar.
Article
em En
| MEDLINE
| ID: mdl-31618473
ABSTRACT
BACKGROUND:
Reflectance confocal microscopy (RCM) is a non-invasive imaging technique that provides dynamic information and allows in vivo monitoring, with excellent histologic correlation. In the last decade, the use of RCM for cutaneous T-cell lymphomas (CTCL) has been reported. CTCL may require multiple biopsies for diagnosis due to its equivocal clinical presentation. RCM was described as a possible tool to help determine the best site for skin biopsy. This study aims to systematically review all RCM features reported in literature for CTCL.METHOD:
A systematic literature search concerning CTCL evaluated by RCM was performed in eight electronic databases until May 2019 following PRISMA-DTA quality assessment.RESULTS:
Eighteen RCM features were described in patients with CTCL. The most frequent were interface dermatitis (89%), epidermal lymphocytes (82%), epidermal architectural disarray (81%), and vesicle-like structure (Pautrier microabscess) (51%).CONCLUSION:
In order to establish comparable parameters among the studies identified, we proposed descriptors for CTCL features and a grading system to quantify them. This will facilitate to define the role of RCM in the diagnosis and monitoring of CTCL patients.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfoma Cutâneo de Células T
/
Microscopia Confocal
/
Dermoscopia
Tipo de estudo:
Prognostic_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
J Cutan Pathol
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Austrália