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A novel molecular mechanism to explain mutations of the HCV protease associated with resistance against covalently bound inhibitors.
Nazario de Moraes, Leonardo; Tommasini Grotto, Rejane Maria; Targino Valente, Guilherme; de Carvalho Sampaio, Heloisa; Magro, Angelo José; Fogaça, Lauana; Wolf, Ivan Rodrigo; Perahia, David; Faria Silva, Giovanni; Plana Simões, Rafael.
Afiliação
  • Nazario de Moraes L; Sao Paulo State University (UNESP), School of Agriculture, Department of Bioprocess and Biotechnology, Avenue Universitária, 3780, Botucatu, SP, Brazil.
  • Tommasini Grotto RM; Sao Paulo State University (UNESP), School of Agriculture, Department of Bioprocess and Biotechnology, Avenue Universitária, 3780, Botucatu, SP, Brazil; Sao Paulo State University (UNESP), Medical School, Blood Center, Avenue Prof. Mário Rubens Guimarães Montenegro, s/n, Botucatu, SP, Brazil.
  • Targino Valente G; Sao Paulo State University (UNESP), School of Agriculture, Department of Bioprocess and Biotechnology, Avenue Universitária, 3780, Botucatu, SP, Brazil; Max Planck Institut for Heart and Lung Research, Ludwigstraße 43, 61231, Bad Nauheim, Germany.
  • de Carvalho Sampaio H; Sao Paulo State University (UNESP), Medical School, Blood Center, Avenue Prof. Mário Rubens Guimarães Montenegro, s/n, Botucatu, SP, Brazil.
  • Magro AJ; Sao Paulo State University (UNESP), School of Agriculture, Department of Bioprocess and Biotechnology, Avenue Universitária, 3780, Botucatu, SP, Brazil; Sao Paulo State University (UNESP), Medical School, Blood Center, Avenue Prof. Mário Rubens Guimarães Montenegro, s/n, Botucatu, SP, Brazil; Sao Pa
  • Fogaça L; Sao Paulo State University (UNESP), School of Agriculture, Department of Bioprocess and Biotechnology, Avenue Universitária, 3780, Botucatu, SP, Brazil; Sao Paulo State University (UNESP), Institute of Biosciences, Street Prof. Dr. Antônio Celso Wagner Zanin, 250, Botucatu, SP, Brazil.
  • Wolf IR; Sao Paulo State University (UNESP), Institute of Biosciences, Street Prof. Dr. Antônio Celso Wagner Zanin, 250, Botucatu, SP, Brazil.
  • Perahia D; École Normale Supérieure Paris-Saclay, Laboratory of Biology and Applied Pharmacology, Cachan, 94235, France.
  • Faria Silva G; Sao Paulo State University (UNESP), Medical School, Blood Center, Avenue Prof. Mário Rubens Guimarães Montenegro, s/n, Botucatu, SP, Brazil.
  • Plana Simões R; Sao Paulo State University (UNESP), School of Agriculture, Department of Bioprocess and Biotechnology, Avenue Universitária, 3780, Botucatu, SP, Brazil; Sao Paulo State University (UNESP), Medical School, Blood Center, Avenue Prof. Mário Rubens Guimarães Montenegro, s/n, Botucatu, SP, Brazil. Electr
Virus Res ; 274: 197778, 2019 12.
Article em En | MEDLINE | ID: mdl-31618615
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Proteínas não Estruturais Virais / Hepacivirus / Farmacorresistência Viral Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: Virus Res Assunto da revista: VIROLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Proteínas não Estruturais Virais / Hepacivirus / Farmacorresistência Viral Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: Virus Res Assunto da revista: VIROLOGIA Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Brasil