Immunotherapeutic Challenges for Pediatric Cancers.
Mol Ther Oncolytics
; 15: 38-48, 2019 Dec 20.
Article
em En
| MEDLINE
| ID: mdl-31650024
ABSTRACT
Solid tumors contain a mixture of malignant cells and non-malignant infiltrating cells that often create a chronic inflammatory and immunosuppressive microenvironment that restricts immunotherapeutic approaches. Although childhood and adult cancers share some similarities related to microenvironmental changes, pediatric cancers are unique, and adult cancer practices may not be wholly applicable to our pediatric patients. This review highlights the differences in tumorigenesis, viral infection, and immunologic response between children and adults that need to be considered when trying to apply experiences from experimental therapies in adult cancer patients to pediatric cancers.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Mol Ther Oncolytics
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Estados Unidos