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Corynebacterium diphtheriae bloodstream infection: the role of antitoxin.
Sutton-Fitzpatrick, Una; Grant, Conor; Nashev, Dimitar; Fleming, Catherine.
Afiliação
  • Sutton-Fitzpatrick U; Clinical Microbiology, Galway University Hospitals, Galway, Ireland suttonfu@tcd.ie.
  • Grant C; Infectious Diseases, Galway University Hospitals, Galway, Ireland.
  • Nashev D; Clinical Microbiology, Galway University Hospitals, Galway, Ireland.
  • Fleming C; Infectious Diseases, Galway University Hospitals, Galway, Ireland.
BMJ Case Rep ; 12(11)2019 Nov 02.
Article em En | MEDLINE | ID: mdl-31678926
ABSTRACT
A 65-year-old male patient presented with fever, fast atrial fibrillation and frank haematuria on return to Ireland from travel in East Africa. He had a systolic murmur leading to a clinical suspicion of endocarditis. He had no specific clinical features of diphtheria. Blood cultures were taken and empiric therapy commenced with benzylpenicillin, vancomycin and gentamicin. Corynebacterium diphtheriae was detected on blood culture. The isolate was submitted to a reference laboratory for evaluation of toxigenicity. While initially there was concern regarding the possibility of myocarditis, a clinical decision was made not to administer diphtheria antitoxin in the absence of clinical features of respiratory diphtheria, in the presence of invasive infection and with presumptive previous immunisation. There is no specific guidance on the role of antitoxin in this setting. The issue is not generally addressed in previous reports of C. diphtheriae blood stream infection.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Corynebacterium diphtheriae / Infecções por Corynebacterium Tipo de estudo: Guideline / Prognostic_studies Limite: Aged / Humans / Male Idioma: En Revista: BMJ Case Rep Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Irlanda

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Corynebacterium diphtheriae / Infecções por Corynebacterium Tipo de estudo: Guideline / Prognostic_studies Limite: Aged / Humans / Male Idioma: En Revista: BMJ Case Rep Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Irlanda