Baseline and Exercise Predictors of VËO2peak in Systolic Heart Failure Patients: Results from SMARTEX-HF.
Med Sci Sports Exerc
; 52(4): 810-819, 2020 04.
Article
em En
| MEDLINE
| ID: mdl-31688648
ABSTRACT
PURPOSE:
This study aimed to investigate baseline, exercise testing, and exercise training-mediated predictors of change in peak oxygen uptake (VËO2peak) from baseline to 12-wk follow-up (ΔVËO2peak) in a post hoc analysis from the SMARTEX Heart Failure trial.METHODS:
We studied 215 patients with heart failure with left ventricular ejection fraction (LVEF) ≤35%, and New York Heart Association (NYHA) classes II-III who were randomized to either supervised high-intensity interval training with exercise target intensity of 90%-95% of peak heart rate (HRpeak) or supervised moderate continuous training (MCT) with target intensity of 60%-70% of HRpeak, or who received a recommendation of regular exercise on their own. Predictors of ΔVËO2peak were assessed in two models a logistic regression model comparing highest and lowest tertiles (baseline parameters) and a multivariate linear regression model (test/training/clinical parameters).RESULTS:
The change in VËO2peak in response to the interventions (ΔVËO2peak) varied substantially, from -8.50 to +11.30 mL·kg·min. Baseline NYHA (class II gave higher odds vs III; odds ratio (OR), 7.1 (2.0-24.9); P = 0.002), LVEF (OR per percent, 1.1 (1.0-1.2); P = 0.005), and age (OR per 10 yr, 0.5 (0.3-0.8); P = 0.003) were associated with ΔVËO2peak.In the multivariate linear regression, 34% of the variability in ΔVËO2peak was explained by the increase in exercise training workload, ΔHRpeak between baseline and 12-wk posttesting, age, and ever having smoked.CONCLUSION:
Exercise training response (ΔVËO2peak) correlated negatively with age, LVEF, and NYHA class. The ability to increase workload during the training period and increased ΔHRpeak between baseline and the 12-wk test were associated with a positive outcome.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Consumo de Oxigênio
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Volume Sistólico
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Função Ventricular Esquerda
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Terapia por Exercício
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Insuficiência Cardíaca
Tipo de estudo:
Clinical_trials
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Guideline
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Med Sci Sports Exerc
Ano de publicação:
2020
Tipo de documento:
Article