Melatonin biosynthesis restored by CpG oligodeoxynucleotides attenuates allergic airway inflammation via regulating NLRP3 inflammasome.

Wu, Hui-Mei; Xie, Qiu-Meng; Zhao, Cui-Cui; Xu, Juan; Fan, Xiao-Yun; Fei, Guang-He

Wu, Hui-Mei; Xie, Qiu-Meng; Zhao, Cui-Cui; Xu, Juan; Fan, Xiao-Yun; Fei, Guang-He.

Afiliação

Wu HM; Anhui Geriatric Institute, Department of Geriatric Respiratory and Critical Care, The First Affiliated Hospital of Anhui Medical University, Jixi Road 218, Hefei, Anhui 230022, China. Electronic address: wuhm@ahmu.edu.cn.
Xie QM; Anhui Geriatric Institute, Department of Geriatric Respiratory and Critical Care, The First Affiliated Hospital of Anhui Medical University, Jixi Road 218, Hefei, Anhui 230022, China.
Zhao CC; Anhui Geriatric Institute, Department of Geriatric Respiratory and Critical Care, The First Affiliated Hospital of Anhui Medical University, Jixi Road 218, Hefei, Anhui 230022, China.
Xu J; Anhui Geriatric Institute, Department of Geriatric Respiratory and Critical Care, The First Affiliated Hospital of Anhui Medical University, Jixi Road 218, Hefei, Anhui 230022, China.
Fan XY; Anhui Geriatric Institute, Department of Geriatric Respiratory and Critical Care, The First Affiliated Hospital of Anhui Medical University, Jixi Road 218, Hefei, Anhui 230022, China.
Fei GH; Anhui Geriatric Institute, Department of Geriatric Respiratory and Critical Care, The First Affiliated Hospital of Anhui Medical University, Jixi Road 218, Hefei, Anhui 230022, China. Electronic address: guanghefei@126.com.

Life Sci ; 239: 117067, 2019 Dec 15.

Article em En | MEDLINE | ID: mdl-31738882

Assuntos

Inflamassomos/efeitos dos fármacos; Melatonina/farmacologia; Oligodesoxirribonucleotídeos/farmacologia; Animais; Asma; Líquido da Lavagem Broncoalveolar; Citocinas/metabolismo; Feminino; Hipersensibilidade/metabolismo; Inflamassomos/metabolismo; Inflamassomos/fisiologia; Inflamação/metabolismo; Inflamação/prevenção & controle; Pulmão/metabolismo; Melatonina/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo; Proteína 3 que Contém Domínio de Pirina da Família NLR/fisiologia; Oligodesoxirribonucleotídeos/genética; Oligodesoxirribonucleotídeos/metabolismo; Células Th2; Triptaminas/farmacologia

Palavras-chave

Allergic airway inflammation; Biosynthesis; CpG-ODN; Melatonin; NLRP3 inflammasome

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oligodesoxirribonucleotídeos / Inflamassomos / Melatonina Limite: Animals Idioma: En Revista: Life Sci Ano de publicação: 2019 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google