Repurposing the GNAT Fold in the Initiation of Polyketide Biosynthesis.

Skiba, Meredith A; Tran, Collin L; Dan, Qingyun; Sikkema, Andrew P; Klaver, Zachary; Gerwick, William H; Sherman, David H; Smith, Janet L

Skiba, Meredith A; Tran, Collin L; Dan, Qingyun; Sikkema, Andrew P; Klaver, Zachary; Gerwick, William H; Sherman, David H; Smith, Janet L.

Afiliação

Skiba MA; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA; Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
Tran CL; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Dan Q; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Sikkema AP; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA; Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
Klaver Z; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Gerwick WH; Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92093, USA; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093, USA.
Sherman DH; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA; Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA; Department of Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109, USA; Department of Microbiology and Immunology, University of Michigan
Smith JL; Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA; Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: janetsmith@umich.edu.

Structure ; 28(1): 63-74.e4, 2020 01 07.

Article em En | MEDLINE | ID: mdl-31785925

Assuntos

Acetiltransferases/química; Acetiltransferases/metabolismo; Policetídeos/metabolismo; Cristalografia por Raios X; Humanos; Modelos Moleculares; Domínios Proteicos; Dobramento de Proteína; Estrutura Secundária de Proteína

Palavras-chave

GCN5-related N-acetyltransferase; biosynthesis; natural products; polyketide synthase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acetiltransferases / Policetídeos Limite: Humans Idioma: En Revista: Structure Assunto da revista: BIOLOGIA MOLECULAR / BIOQUIMICA / BIOTECNOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

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