In vitro apoptotic effect on human lymphatic filarial parasite by piperidine derivatives and thymidine reversal study.

Bhoj, Priyanka S; Rao, Sahitya; Bahekar, Sandeep P; Agrawal, Nikita R; Togre, Namdev S; Sharma, Richa; Goswami, Kalyan; Chandak, Hemant S; Patil, Mandakini B

Bhoj, Priyanka S; Rao, Sahitya; Bahekar, Sandeep P; Agrawal, Nikita R; Togre, Namdev S; Sharma, Richa; Goswami, Kalyan; Chandak, Hemant S; Patil, Mandakini B.

Afiliação

Bhoj PS; Department of Biochemistry, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha, 442 102, India.
Rao S; Department of Biochemistry, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha, 442 102, India.
Bahekar SP; Department of Chemistry, G. S. Science, Arts and Commerce College, Khamgaon, 444303, India.
Agrawal NR; Department of Chemistry, G. S. Science, Arts and Commerce College, Khamgaon, 444303, India.
Togre NS; Department of Biochemistry, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha, 442 102, India.
Sharma R; Department of Biochemistry, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha, 442 102, India.
Goswami K; Department of Biochemistry, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha, 442 102, India. goswamikln@gmail.com.
Chandak HS; Department of Chemistry, G. S. Science, Arts and Commerce College, Khamgaon, 444303, India. chemants@gmail.com.
Patil MB; University Department of Biochemistry, RTM Nagpur University, Nagpur, 440033, India.

Parasitol Res ; 119(1): 165-175, 2020 Jan.

Article em En | MEDLINE | ID: mdl-31807868

Assuntos

Brugia Malayi/efeitos dos fármacos; Filariose Linfática/tratamento farmacológico; Filaricidas/farmacologia; Piperidinas/farmacologia; Timidilato Sintase/antagonistas & inibidores; Animais; Chalcona/farmacologia; Replicação do DNA/efeitos dos fármacos; Filariose Linfática/parasitologia; Antagonistas do Ácido Fólico/farmacologia; Humanos; Microfilárias/efeitos dos fármacos; Simulação de Acoplamento Molecular; Tetra-Hidrofolato Desidrogenase/efeitos dos fármacos; Sais de Tetrazólio; Timidina/farmacologia

Palavras-chave

Apoptosis; Brugia malayi; Folate metabolism; Piperidine; Thymidylate synthase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperidinas / Timidilato Sintase / Filariose Linfática / Brugia Malayi / Filaricidas Limite: Animals / Humans Idioma: En Revista: Parasitol Res Assunto da revista: PARASITOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Índia

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