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Stratification of Prognosis in Patients With Ampullary Carcinoma After Surgery by Preoperative Platelet-to-lymphocyte Ratio and Conventional Tumor Markers.
Kawaida, Hiromichi; Kono, Hiroshi; Amemiya, Hidetake; Hosomura, Naohiro; Watanabe, Mitsuaki; Saito, Ryo; Maruyama, Suguru; Shimizu, Hiroki; Furuya, Shinji; Akaike, Hidenori; Kawaguchi, Yoshihiko; Sudo, Makoto; Matusda, Masanori; Itakura, Jun; Shindo, Hiroko; Takahashi, E I; Takano, Shinichi; Fukasawa, Mitsuharu; Satou, Tadashi; Nakazawa, Tadao; Enomoto, Nobuyuki; Fujii, Hideki; Ichikawa, Daisuke.
Afiliação
  • Kawaida H; First Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan kawaidah@yamanashi.ac.jp.
  • Kono H; First Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
  • Amemiya H; First Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
  • Hosomura N; First Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
  • Watanabe M; First Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
  • Saito R; First Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
  • Maruyama S; First Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
  • Shimizu H; First Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
  • Furuya S; First Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
  • Akaike H; First Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
  • Kawaguchi Y; First Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
  • Sudo M; First Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
  • Matusda M; First Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
  • Itakura J; First Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
  • Shindo H; First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
  • Takahashi EI; First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
  • Takano S; First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
  • Fukasawa M; First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
  • Satou T; First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
  • Nakazawa T; Department of Human Pathology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
  • Enomoto N; First Department of Internal Medicine, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
  • Fujii H; First Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
  • Ichikawa D; First Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
Anticancer Res ; 39(12): 6923-6929, 2019 Dec.
Article em En | MEDLINE | ID: mdl-31810963
ABSTRACT
BACKGROUND/

AIM:

The platelet-to-lymphocyte ratio (PLR) has recently been suggested as a new predictor of the prognosis in several carcinoma types. However, the clinical impact remains controversial in patients with ampullary carcinoma. Thus, the aim of this study was to investigate other useful biomarkers for identifying poor prognosis in patients with ampullary carcinoma. PATIENTS AND

METHODS:

Forty-one patients with ampullary carcinoma underwent pancreaticoduodenectomy (PD) with curative resection between April 2000 and April 2017. Various clinicopathological findings of the patients and their tumors were evaluated as potential prognostic factors which might enable better stratification of prognosis.

RESULTS:

Platelet-to-lymphocyte ratio, as well as other markers, was found to be a prognostic factor in patients with ampullary carcinoma. The 2-year disease-free survival percentage was significantly higher in the group with low PLR than in the high PLR group (70.2% vs. 28.6%; p=0.005). Combinational analysis of the PLR and conventional TMs enabled us to stratify prognosis of the patients more clearly than by each marker alone.

CONCLUSION:

PLR was a useful prognostic factor for patients with ampullary cancer. The combination of preoperative PLR and conventional TMs markers may be powerful predictive factors for postoperative prognosis in patients with ampullary carcinoma following PD.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Ampola Hepatopancreática / Carcinoma Ductal Pancreático Tipo de estudo: Prognostic_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Anticancer Res Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Japão
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Ampola Hepatopancreática / Carcinoma Ductal Pancreático Tipo de estudo: Prognostic_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Anticancer Res Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Japão