Changes in brainstem excitatory and inhibitory pathways in dry eye syndrome.
Neurosci Lett
; 718: 134726, 2020 01 23.
Article
em En
| MEDLINE
| ID: mdl-31884018
ABSTRACT
BACKGROUND:
We hypothesized that there may be changes in sensory integration pathways in patients with dry eye. To confront this issue, we analyzed blink reflex (BR), prepulse modulation (PPM) of BR, and excitability recovery of BR to paired stimuli in 17 experimental subjects with dry eye syndrome.METHOD:
We included 17 experimental subjects, 8 with primary and 9 with secondary, dry eye syndrome. We also examined a control group of 14 age and gender matched control subjects. After clinical evaluation, we recorded BR, PPM of BR (at 50 and 100â¯ms intervals) and BR percentage recovery to paired stimulation (at 300 and 500â¯ms intervals).RESULTS:
None of the patients had any spasm activity. Experimental subjects had significantly larger R2 and R2c AUCs, significantly greater excitability recovery at 300â¯ms interval and significantly reduced R2 and R2c prepulse inhibition, in comparison to control subjects. Experimental subjects with primary dry eye syndrome had higher number of spontaneous blinks than experimental subjects with secondary dry eye syndrome (54.0⯱â¯10.3 for primary dry eye and 43.5⯱â¯13.3 secondary dry eye).CONCLUSION:
Our results are compatible with increased excitability and abnormalities in sensorimotor integration in blink reflex circuits of patients with dry eye. This suggests the development of adaptive changes in brainstem synaptic activity, aimed at facilitation of blinking in the context of increased sensory input from corneal irritation.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tronco Encefálico
/
Síndromes do Olho Seco
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Neurosci Lett
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Turquia