AE Succinimide, an Analogue of Methyllycaconitine, When Bound Generates a Nonconducting Conformation of the &#945;4ß2 Nicotinic Acetylcholine Receptor.

Qudah, Taima; Quek, Gracia X; Indurthi, Dinesh; Karim, Nasiara; Halliday, Jill I; Absalom, Nathan; McLeod, Malcolm D; Chebib, Mary

AE Succinimide, an Analogue of Methyllycaconitine, When Bound Generates a Nonconducting Conformation of the α4ß2 Nicotinic Acetylcholine Receptor.

Qudah, Taima; Quek, Gracia X; Indurthi, Dinesh; Karim, Nasiara; Halliday, Jill I; Absalom, Nathan; McLeod, Malcolm D; Chebib, Mary.

Afiliação

Qudah T; Brain and Mind Centre , School of Pharmacy, Faculty of Medicine and Health , Sydney , NSW 2050 , The University of Sydney.
Quek GX; Brain and Mind Centre , School of Pharmacy, Faculty of Medicine and Health , Sydney , NSW 2050 , The University of Sydney.
Indurthi D; Brain and Mind Centre , School of Pharmacy, Faculty of Medicine and Health , Sydney , NSW 2050 , The University of Sydney.
Karim N; Brain and Mind Centre , School of Pharmacy, Faculty of Medicine and Health , Sydney , NSW 2050 , The University of Sydney.
Halliday JI; Research School of Chemistry, College of Science , The Australian National University , Canberra , ACT 2601 , Australia.
Absalom N; Brain and Mind Centre , School of Pharmacy, Faculty of Medicine and Health , Sydney , NSW 2050 , The University of Sydney.
McLeod MD; Research School of Chemistry, College of Science , The Australian National University , Canberra , ACT 2601 , Australia.
Chebib M; Brain and Mind Centre , School of Pharmacy, Faculty of Medicine and Health , Sydney , NSW 2050 , The University of Sydney.

ACS Chem Neurosci ; 11(3): 344-355, 2020 02 05.

Article em En | MEDLINE | ID: mdl-31898891

Assuntos

Aconitina/análogos & derivados; Potenciais da Membrana/efeitos dos fármacos; Antagonistas Nicotínicos/farmacologia; Receptores Nicotínicos/efeitos dos fármacos; Succinimidas/farmacologia; Acetilcolina/metabolismo; Aconitina/farmacologia; Animais; Sítios de Ligação/efeitos dos fármacos; Oócitos/efeitos dos fármacos; Oócitos/metabolismo; Subunidades Proteicas/metabolismo; Receptores Nicotínicos/metabolismo; Succinimidas/química; Xenopus laevis/metabolismo; Receptor Nicotínico de Acetilcolina alfa7/efeitos dos fármacos; Receptor Nicotínico de Acetilcolina alfa7/metabolismo

Palavras-chave

Ligand-gated ion channel; methyllycaconitine; nicotinic acetylcholine receptor; noncompetitive antagonist; substituted cysteine accessibility method

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Succinimidas / Aconitina / Receptores Nicotínicos / Antagonistas Nicotínicos / Potenciais da Membrana Limite: Animals Idioma: En Revista: ACS Chem Neurosci Ano de publicação: 2020 Tipo de documento: Article

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