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Discovery of Small Molecules That Target the Phosphatidylinositol (3,4,5) Trisphosphate (PIP3)-Dependent Rac Exchanger 1 (P-Rex1) PIP3-Binding Site and Inhibit P-Rex1-Dependent Functions in Neutrophils.
Cash, Jennifer N; Chandan, Naincy R; Hsu, Alan Y; Sharma, Prateek V; Deng, Qing; Smrcka, Alan V; Tesmer, John J G.
Afiliação
  • Cash JN; Departments of Pharmacology and Biological Chemistry, Life Sciences Institute, University of Michigan, Ann Arbor, Michigan (J.N.C., P.V.S.); Department of Pharmacology, University of Michigan, Ann Arbor, Michigan (N.R.C., A.V.S.); and Departments of Biological Sciences (A.Y.H., Q.D., J.J.G.T.) and M
  • Chandan NR; Departments of Pharmacology and Biological Chemistry, Life Sciences Institute, University of Michigan, Ann Arbor, Michigan (J.N.C., P.V.S.); Department of Pharmacology, University of Michigan, Ann Arbor, Michigan (N.R.C., A.V.S.); and Departments of Biological Sciences (A.Y.H., Q.D., J.J.G.T.) and M
  • Hsu AY; Departments of Pharmacology and Biological Chemistry, Life Sciences Institute, University of Michigan, Ann Arbor, Michigan (J.N.C., P.V.S.); Department of Pharmacology, University of Michigan, Ann Arbor, Michigan (N.R.C., A.V.S.); and Departments of Biological Sciences (A.Y.H., Q.D., J.J.G.T.) and M
  • Sharma PV; Departments of Pharmacology and Biological Chemistry, Life Sciences Institute, University of Michigan, Ann Arbor, Michigan (J.N.C., P.V.S.); Department of Pharmacology, University of Michigan, Ann Arbor, Michigan (N.R.C., A.V.S.); and Departments of Biological Sciences (A.Y.H., Q.D., J.J.G.T.) and M
  • Deng Q; Departments of Pharmacology and Biological Chemistry, Life Sciences Institute, University of Michigan, Ann Arbor, Michigan (J.N.C., P.V.S.); Department of Pharmacology, University of Michigan, Ann Arbor, Michigan (N.R.C., A.V.S.); and Departments of Biological Sciences (A.Y.H., Q.D., J.J.G.T.) and M
  • Smrcka AV; Departments of Pharmacology and Biological Chemistry, Life Sciences Institute, University of Michigan, Ann Arbor, Michigan (J.N.C., P.V.S.); Department of Pharmacology, University of Michigan, Ann Arbor, Michigan (N.R.C., A.V.S.); and Departments of Biological Sciences (A.Y.H., Q.D., J.J.G.T.) and M
  • Tesmer JJG; Departments of Pharmacology and Biological Chemistry, Life Sciences Institute, University of Michigan, Ann Arbor, Michigan (J.N.C., P.V.S.); Department of Pharmacology, University of Michigan, Ann Arbor, Michigan (N.R.C., A.V.S.); and Departments of Biological Sciences (A.Y.H., Q.D., J.J.G.T.) and M
Mol Pharmacol ; 97(3): 226-236, 2020 03.
Article em En | MEDLINE | ID: mdl-31900312
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfatos de Fosfatidilinositol / Fatores de Troca do Nucleotídeo Guanina / Descoberta de Drogas / Neutrófilos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Mol Pharmacol Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfatos de Fosfatidilinositol / Fatores de Troca do Nucleotídeo Guanina / Descoberta de Drogas / Neutrófilos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Mol Pharmacol Ano de publicação: 2020 Tipo de documento: Article