Dexmedetomidine Post-Conditioning Alleviates Cerebral Ischemia-Reperfusion Injury in Rats by Inhibiting High Mobility Group Protein B1 Group (HMGB1)/Toll-Like Receptor 4 (TLR4)/Nuclear Factor kappa B (NF-&#954;B) Signaling Pathway.

Zhai, Yongyi; Zhu, Yulin; Liu, Jingying; Xie, Kun; Yu, Jingui; Yu, Lingzhi; Deng, Hongyan

Dexmedetomidine Post-Conditioning Alleviates Cerebral Ischemia-Reperfusion Injury in Rats by Inhibiting High Mobility Group Protein B1 Group (HMGB1)/Toll-Like Receptor 4 (TLR4)/Nuclear Factor kappa B (NF-κB) Signaling Pathway.

Zhai, Yongyi; Zhu, Yulin; Liu, Jingying; Xie, Kun; Yu, Jingui; Yu, Lingzhi; Deng, Hongyan.

Afiliação

Zhai Y; Department of Rehabilitation, Linzi District People's Hospital, Zibo, Shandong, China (mainland).
Zhu Y; Department of Anesthesiology, Yantaishan Hospital, Yantai, Shandong, China (mainland).
Liu J; Department of Obstetrics, Yantaishan Hospital, Yantai, Shandong, China (mainland).
Xie K; Department of Anesthesiology, The Second Hospital of Shandong University, Jinan, Shandong, China (mainland).
Yu J; Department of Anesthesiology, Qilu Hospital of Shandong University, Jinan, Shandong, China (mainland).
Yu L; Department of Pain, Jinan Central Hospital affiliated to Shandong University, Jinan, Shandong, China (mainland).
Deng H; Department of Anesthesiology, Haiyang People's Hospital, Haiyang, Shandong, China (mainland).

Med Sci Monit ; 26: e918617, 2020 Jan 08.

Article em En | MEDLINE | ID: mdl-31912804

Assuntos

Isquemia Encefálica/tratamento farmacológico; Dexmedetomidina/farmacologia; Proteína HMGB1/antagonistas & inibidores; NF-kappa B/antagonistas & inibidores; Traumatismo por Reperfusão/tratamento farmacológico; Receptor 4 Toll-Like/antagonistas & inibidores; Animais; Proteína HMGB1/metabolismo; Peróxido de Hidrogênio/farmacologia; Inflamação; Masculino; Inibidor de NF-kappaB alfa/metabolismo; NF-kappa B/metabolismo; Ratos; Ratos Sprague-Dawley; Traumatismo por Reperfusão/metabolismo; Transdução de Sinais/efeitos dos fármacos; Receptor 4 Toll-Like/metabolismo; Fator de Necrose Tumoral alfa/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Traumatismo por Reperfusão / Isquemia Encefálica / NF-kappa B / Dexmedetomidina / Proteína HMGB1 / Receptor 4 Toll-Like Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Med Sci Monit Assunto da revista: MEDICINA Ano de publicação: 2020 Tipo de documento: Article

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