Simulation of the efficiency of inner hair cell secretion in the auditory pathway.
Annu Int Conf IEEE Eng Med Biol Soc
; 2019: 2332-2335, 2019 Jul.
Article
em En
| MEDLINE
| ID: mdl-31946367
ABSTRACT
Sound coding involves several stages of processing along the auditory path. Specifically, the Inner Hair Cells (IHC) act as sensory receptors and transduce acoustic information -frequency, intensity and duration of the stimulus- into neuronal signals. In this work, a stochastic model was implemented to achieve a better understanding of the IHC-auditory nerve synapse, specifically, the process of Ready Releasable Pool (RRP) vesicle exocytosis, a complicated process to study experimentally because current protocols do not provide adequate temporal resolution, in the order of milliseconds. The presented model allows predicting the efficiency of glutamate release towards explaining maturation changes or disease impacts in the auditory pathway.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vias Auditivas
/
Células Ciliadas Auditivas Internas
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Annu Int Conf IEEE Eng Med Biol Soc
Ano de publicação:
2019
Tipo de documento:
Article