Oxygenated Cyclohexene Derivatives and Other Constituents from the Roots of Monanthotaxis trichocarpa.
J Nat Prod
; 83(2): 210-215, 2020 02 28.
Article
em En
| MEDLINE
| ID: mdl-31986029
ABSTRACT
Three new oxygenated cyclohexene derivatives, trichocarpeols A (1), B (2), and C (3), along with nine known secondary metabolites, were isolated from the methanolic root extract of Monanthotaxis trichocarpa. They were identified by NMR spectroscopic and mass spectrometric analyses, and the structure of trichocarpeol A (1) was confirmed by single-crystal X-ray diffraction. Out of the 12 isolated natural products, uvaretin (4) showed activity against the Gram-positive bacterium Bacillus subtilis with a MIC value of 18 µM. None of the isolated metabolites was active against the Gram-negative Escherichia coli at a â¼5 mM (2000 µg/mL) concentration. Whereas 4 showed cytotoxicity at EC50 10.2 µM against the MCF-7 human breast cancer cell line, the other compounds were inactive or not tested.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxigênio
/
Bacillus subtilis
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Raízes de Plantas
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Annonaceae
/
Cicloexenos
/
Antibacterianos
Limite:
Humans
Idioma:
En
Revista:
J Nat Prod
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Tanzânia