Neuropsychiatric Effects on Decision-Making in Early Alzheimer Disease.
J Geriatr Psychiatry Neurol
; 33(2): 68-72, 2020 03.
Article
em En
| MEDLINE
| ID: mdl-32013736
ABSTRACT
BACKGROUND:
Neuropsychiatric symptoms can impact decision-making in patients with Alzheimer disease (AD).METHODS:
Using a simple decision-making task, a variant of the ultimatum game (UG) modified to control feelings of unfairness, this study investigated rejection responses among responders to unfair offers. The UG was administered to 11 patients with AD, 10 comparably demented patients with behavioral variant frontotemporal dementia (bvFTD), and 9 healthy controls (HC). The results were further compared with differences on the caregiver Neuropsychiatric Inventory (NPI).RESULTS:
Overall, patients with AD significantly rejected more total offers than did the patients with bvFTD and the HC (P < .01). On the NPI, the only domain that was significantly worse among the patients with AD compared to the other groups was dysphoria/depression.CONCLUSIONS:
These results suggest that early AD can be distinguished based on increased rejections of offers in decision-making, possibly consequent to a heightened sense of unfairness from dysphoria/depression.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tomada de Decisões
/
Doença de Alzheimer
Limite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Geriatr Psychiatry Neurol
Assunto da revista:
GERIATRIA
/
NEUROLOGIA
/
PSIQUIATRIA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Estados Unidos