Probing Pedomorphy and Prolonged Lifespan in Naked Mole-Rats and Dwarf Mice.
Physiology (Bethesda)
; 35(2): 96-111, 2020 03 01.
Article
em En
| MEDLINE
| ID: mdl-32024425
ABSTRACT
Pedomorphy, maintenance of juvenile traits throughout life, is most pronounced in extraordinarily long-lived naked mole-rats. Many of these traits (e.g., slow growth rates, low hormone levels, and delayed sexual maturity) are shared with spontaneously mutated, long-lived dwarf mice. Although some youthful traits likely evolved as adaptations to subterranean habitats (e.g., thermolability), the nature of these intrinsic pedomorphic features may also contribute to their prolonged youthfulness, longevity, and healthspan.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
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Adaptação Fisiológica
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Estresse Oxidativo
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Nanismo
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Longevidade
Limite:
Animals
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Humans
Idioma:
En
Revista:
Physiology (Bethesda)
Assunto da revista:
FISIOLOGIA
Ano de publicação:
2020
Tipo de documento:
Article