Structural optimality and neurogenetic expression mediate functional dynamics in the human brain.
Hum Brain Mapp
; 41(8): 2229-2243, 2020 06 01.
Article
em En
| MEDLINE
| ID: mdl-32027077
ABSTRACT
The human brain exhibits a rich functional repertoire in terms of complex functional connectivity patterns during rest and tasks. However, how this is developed upon a fixed structural anatomy remains poorly understood. Here we investigated the hypothesis that resting state functional connectivity and the manner in which it changes during tasks related to a set of underlying structural connections that promote optimal communication in the brain. We used a game-theoretic model to identify such optimal connections in the structural connectome of 50 healthy individuals and subsequently used the optimal structural connections to predict resting-state functional connectivity with high accuracy. In contrast, we found that nonoptimal connections accurately predicted functional connectivity during a working memory task. We further found that this balance between optimal and nonoptimal connections between brain regions was associated with a specific gene expression linked to neurotransmission. This multimodal evidence shows for the first time that structure-function relationships in the human brain are related to how brain networks navigate information along different white matter connections as well as the brain's underlying genetic profile.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Expressão Gênica
/
Transmissão Sináptica
/
Neuroimagem
/
Memória de Curto Prazo
/
Rede Nervosa
Tipo de estudo:
Prognostic_studies
Limite:
Adult
/
Humans
Idioma:
En
Revista:
Hum Brain Mapp
Assunto da revista:
CEREBRO
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Reino Unido