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18F-Labeled dihydromethidine: positron emission tomography radiotracer for imaging of reactive oxygen species in intact brain.
Egami, Hiromichi; Nakagawa, Satoshi; Katsura, Yuki; Kanazawa, Masakatsu; Nishiyama, Shingo; Sakai, Toshihiro; Arano, Yasushi; Tsukada, Hideo; Inoue, Osamu; Todoroki, Kenichiro; Hamashima, Yoshitaka.
Afiliação
  • Egami H; School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. todoroki@u-shizuoka-ken.ac.jp hamashima@u-shizuoka-ken.ac.jp.
  • Nakagawa S; School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. todoroki@u-shizuoka-ken.ac.jp hamashima@u-shizuoka-ken.ac.jp.
  • Katsura Y; School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. todoroki@u-shizuoka-ken.ac.jp hamashima@u-shizuoka-ken.ac.jp.
  • Kanazawa M; Central Research Laboratory, Hamamatsu Photonics K. K., 5000 Hirakuchi, Hamakita-Ku, Hamamatsu, Shizuoka 434-8601, Japan.
  • Nishiyama S; Central Research Laboratory, Hamamatsu Photonics K. K., 5000 Hirakuchi, Hamakita-Ku, Hamamatsu, Shizuoka 434-8601, Japan.
  • Sakai T; Hanwa Intelligent Medical Center, Hanwa Daini Senboku Hospital, 3176 Fukaikita, Naka-ku, Sakai, Osaka, Japan.
  • Arano Y; Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8675, Japan.
  • Tsukada H; Central Research Laboratory, Hamamatsu Photonics K. K., 5000 Hirakuchi, Hamakita-Ku, Hamamatsu, Shizuoka 434-8601, Japan.
  • Inoue O; Hanwa Intelligent Medical Center, Hanwa Daini Senboku Hospital, 3176 Fukaikita, Naka-ku, Sakai, Osaka, Japan.
  • Todoroki K; School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. todoroki@u-shizuoka-ken.ac.jp hamashima@u-shizuoka-ken.ac.jp.
  • Hamashima Y; School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. todoroki@u-shizuoka-ken.ac.jp hamashima@u-shizuoka-ken.ac.jp.
Org Biomol Chem ; 18(13): 2387-2391, 2020 04 01.
Article em En | MEDLINE | ID: mdl-32073113
ABSTRACT
Dihydromethidine (DHM) labeled with 18F at the para position of the peripheral benzene ring was designed as a positron emission tomography (PET) radiotracer for non-invasive imaging of reactive oxygen species (ROS). This compound readily crosses the blood-brain barrier and is oxidized by ROS, and the oxidation product is retained intracellularly. PET imaging of ROS-producing rat brain microinfused with sodium nitroprusside identified specific brain regions with high ROS concentrations. This tracer should be useful for studies of the pathophysiological roles of ROS, and in the diagnosis of neurodegenerative diseases.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenantridinas / Encéfalo / Espécies Reativas de Oxigênio / Compostos Radiofarmacêuticos Limite: Animals Idioma: En Revista: Org Biomol Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenantridinas / Encéfalo / Espécies Reativas de Oxigênio / Compostos Radiofarmacêuticos Limite: Animals Idioma: En Revista: Org Biomol Chem Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2020 Tipo de documento: Article