Chronic Cannabidiol Administration Fails to Diminish Blood Pressure in Rats with Primary and Secondary Hypertension Despite Its Effects on Cardiac and Plasma Endocannabinoid System, Oxidative Stress and Lipid Metabolism.

Remiszewski, Patryk; Jarocka-Karpowicz, Iwona; Biernacki, Michal; Jastrzab, Anna; Schlicker, Eberhard; Toczek, Marek; Harasim-Symbor, Ewa; Pedzinska-Betiuk, Anna; Malinowska, Barbara

Remiszewski, Patryk; Jarocka-Karpowicz, Iwona; Biernacki, Michal; Jastrzab, Anna; Schlicker, Eberhard; Toczek, Marek; Harasim-Symbor, Ewa; Pedzinska-Betiuk, Anna; Malinowska, Barbara.

Afiliação

Remiszewski P; Department of Experimental Physiology and Pathophysiology, Medical University of Bialystok, 15-222 Bialystok, Poland.
Jarocka-Karpowicz I; Department of Analytical Chemistry, Medical University of Bialystok, 15-222 Bialystok, Poland.
Biernacki M; Department of Analytical Chemistry, Medical University of Bialystok, 15-222 Bialystok, Poland.
Jastrzab A; Department of Analytical Chemistry, Medical University of Bialystok, 15-222 Bialystok, Poland.
Schlicker E; Department of Pharmacology and Toxicology, University of Bonn, 53127 Bonn, Germany.
Toczek M; Department of Experimental Physiology and Pathophysiology, Medical University of Bialystok, 15-222 Bialystok, Poland.
Harasim-Symbor E; Department of Physiology, Medical University of Bialystok, 15-222 Bialystok, Poland.
Pedzinska-Betiuk A; Department of Experimental Physiology and Pathophysiology, Medical University of Bialystok, 15-222 Bialystok, Poland.
Malinowska B; Department of Experimental Physiology and Pathophysiology, Medical University of Bialystok, 15-222 Bialystok, Poland.

Int J Mol Sci ; 21(4)2020 Feb 14.

Article em En | MEDLINE | ID: mdl-32075117

Assuntos

Pressão Sanguínea/efeitos dos fármacos; Canabidiol/farmacologia; Metabolismo dos Lipídeos/efeitos dos fármacos; Estresse Oxidativo/efeitos dos fármacos; Amidoidrolases/antagonistas & inibidores; Amidoidrolases/metabolismo; Animais; Ácidos Araquidônicos/sangue; Endocanabinoides/sangue; Ácidos Graxos não Esterificados/metabolismo; Coração/efeitos dos fármacos; Frequência Cardíaca/efeitos dos fármacos; Hipertensão/patologia; Miocárdio/metabolismo; Alcamidas Poli-Insaturadas/sangue; Ratos; Ratos Endogâmicos SHR; Ratos Endogâmicos WKY; Receptores de Canabinoides/metabolismo

Palavras-chave

2-arachidonoylglycerol; DOCA-salt; SHR; anandamide; cannabidiol; cannabinoid receptor; endocannabinoids; oxidative stress

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pressão Sanguínea / Canabidiol / Estresse Oxidativo / Metabolismo dos Lipídeos Limite: Animals Idioma: En Revista: Int J Mol Sci Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Polônia

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google