Noninvasive neuromodulation of the prefrontal cortex in young women with obesity: a randomized clinical trial.
Int J Obes (Lond)
; 44(6): 1279-1290, 2020 06.
Article
em En
| MEDLINE
| ID: mdl-32076105
ABSTRACT
BACKGROUND/OBJECTIVES:
Obesity is associated with reduced neurocognitive performance. Individuals with obesity show decreased activation in the left dorsolateral prefrontal cortex (DLPFC), a key brain region relevant to the regulation of eating behavior. Transcranial direct current stimulation (tDCS) has emerged as a potential technique to correct these abnormalities. However, there is limited information to date, particularly in clinical settings and regarding long-term effects of tDCS. This study aimed to investigate the effects of DLPFC-targeted tDCS in young women with obesity. SUBJECT/METHODS:
Randomized, double-blind, sham-controlled parallel-design clinical trial conducted in 38 women, aged 20-40 years, with BMI 30-35 kg/m2. STUDYDESIGN:
Phase I target engagement (immediate effects of tDCS on working memory performance), Phase II tDCS only (ten sessions, 2 weeks), Phase III tDCS + hypocaloric diet (six sessions, 30% energy intake reduction, 2 weeks, inpatient), Phase IV follow-up at 1, 3, and 6 months. PRIMARYOUTCOME:
change in body weight. SECONDARYOUTCOMES:
change in eating behavior and appetite. Additional analyses effect of Catechol-O-methyl transferase (COMT) gene variability. Data were analyzed as linear mixed models.RESULTS:
There was no group difference in change in body weight during the tDCS intervention. At follow-up, the active group lost less weight than the sham group. In addition, the active group regained weight at 6-month follow-up, compared with sham. Genetic analysis indicated that COMT Met noncarriers were the subgroup that accounted for this paradoxical response in the active group.CONCLUSION:
Our results suggest that in young women with class I obesity, tDCS targeted to the DLPFC does not facilitate weight loss. Indeed, we found indications that tDCS could have a paradoxical effect in this population, possibly connected with individual differences in dopamine availability. Future studies are needed to confirm these findings.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Córtex Pré-Frontal
/
Estimulação Transcraniana por Corrente Contínua
/
Obesidade
Tipo de estudo:
Clinical_trials
/
Prognostic_studies
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Int J Obes (Lond)
Assunto da revista:
METABOLISMO
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Estados Unidos