Structure revision of trichotoxin, a chlorinated polyketide isolated from a Trichodesmium thiebautii bloom.
Tetrahedron Lett
; 57(52): 5864-5867, 2016 Dec 28.
Article
em En
| MEDLINE
| ID: mdl-32153305
ABSTRACT
NMR-guided fractionation of the lipophilic extract of Trichodesmium thiebautii filaments led to the isolation of a phenyl-containing chlorinated polyketide (1) and an alkyne-containing analogue (2). Comparison of spectroscopic and spectrometric data of 1 with the data of the previously reported trichotoxin, strongly suggested that these metabolites were identical and supports a structural revision of trichotoxin and its designation as trichotoxin A. In addition, we report the isolation and characterization of the alkyne-containing analogue trichotoxin B (2). Absolute configuration of 1 and 2 is proposed based on spectroscopic comparison to a close structural analog.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Tetrahedron Lett
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Estados Unidos