Checkpoint Responses to DNA Double-Strand Breaks.
Annu Rev Biochem
; 89: 103-133, 2020 06 20.
Article
em En
| MEDLINE
| ID: mdl-32176524
ABSTRACT
Cells confront DNA damage in every cell cycle. Among the most deleterious types of DNA damage are DNA double-strand breaks (DSBs), which can cause cell lethality if unrepaired or cancers if improperly repaired. In response to DNA DSBs, cells activate a complex DNA damage checkpoint (DDC) response that arrests the cell cycle, reprograms gene expression, and mobilizes DNA repair factors to prevent the inheritance of unrepaired and broken chromosomes. Here we examine the DDC, induced by DNA DSBs, in the budding yeast model system and in mammals.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Saccharomyces cerevisiae
/
DNA
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Proteínas de Saccharomyces cerevisiae
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Reparo do DNA por Junção de Extremidades
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Reparo de DNA por Recombinação
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Pontos de Checagem do Ciclo Celular
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Annu Rev Biochem
Ano de publicação:
2020
Tipo de documento:
Article