Hierarchical binding of copperII to N-truncated Aß4-16 peptide.

ABSTRACT

N-Truncated Aß4-42 displays a high binding affinity with CuII. A mechanistic scheme of the interactions between Aß4-42 and CuII has been proposed using a fluorescence approach. The timescales of different conversion steps were determined. This kinetic mechanism indicates the potential synaptic functions of Aß4-42 during neurotransmission.