Novel Polycondensed Partly Saturated ß-Carbolines Including Ferrocene Derivatives: Synthesis, DFT-Supported Structural Analysis, Mechanism of Some Diastereoselective Transformations and a Preliminary Study of Their in vitro Antiproliferative Effects.

Fodor, Kinga Judit; Hutai, Dániel; Jernei, Tamás; Takács, Angéla; Szász, Zsófia; Sulyok-Eiler, Máté; Harmat, Veronika; Oláh Szabó, Rita; Schlosser, Gitta; Hudecz, Ferenc; Kohidai, László; Csámpai, Antal

Fodor, Kinga Judit; Hutai, Dániel; Jernei, Tamás; Takács, Angéla; Szász, Zsófia; Sulyok-Eiler, Máté; Harmat, Veronika; Oláh Szabó, Rita; Schlosser, Gitta; Hudecz, Ferenc; Kohidai, László; Csámpai, Antal.

Afiliação

Fodor KJ; Department of Organic Chemistry, Eötvös Loránd University (ELTE) Budapest Pázmány P. sétány 1/A, H-1117 Budapest, Hungary.
Hutai D; Department of Organic Chemistry, Eötvös Loránd University (ELTE) Budapest Pázmány P. sétány 1/A, H-1117 Budapest, Hungary.
Jernei T; MTA-ELTE Research Group of Peptide Chemistry, Budapest Pázmány P. sétány 1/A, H-1117 Budapest, Hungary.
Takács A; Department of Genetics, Cell- and Immunobiology, Semmelweis University, H-1089 Budapest, Nagyvárad tér 4, Hungary.
Szász Z; Department of Genetics, Cell- and Immunobiology, Semmelweis University, H-1089 Budapest, Nagyvárad tér 4, Hungary.
Sulyok-Eiler M; Laboratory of Structural Chemistry and Biology, Institute of Chemistry, Eötvös Loránd University, Budapest Pázmány P. sétány 1/A, H-1117 Budapest, Hungary.
Harmat V; Laboratory of Structural Chemistry and Biology, Institute of Chemistry, Eötvös Loránd University, Budapest Pázmány P. sétány 1/A, H-1117 Budapest, Hungary.
Oláh Szabó R; MTA-ELTE Research Group of Peptide Chemistry, Budapest Pázmány P. sétány 1/A, H-1117 Budapest, Hungary.
Schlosser G; MTA-ELTE Research Group of Peptide Chemistry, Budapest Pázmány P. sétány 1/A, H-1117 Budapest, Hungary.
Hudecz F; Department of Analytical Chemistry, Eötvös Loránd University (ELTE), Budapest, Pázmány P. sétány 1/A, H-1117 Budapest, Hungary.
Kohidai L; Department of Organic Chemistry, Eötvös Loránd University (ELTE) Budapest Pázmány P. sétány 1/A, H-1117 Budapest, Hungary.
Csámpai A; MTA-ELTE Research Group of Peptide Chemistry, Budapest Pázmány P. sétány 1/A, H-1117 Budapest, Hungary.

Molecules ; 25(7)2020 Mar 31.

Article em En | MEDLINE | ID: mdl-32244444

Assuntos

Carbolinas/química; Compostos Ferrosos/química; Metalocenos/química; Antineoplásicos/síntese química; Antineoplásicos/química; Antineoplásicos/farmacologia; Carbolinas/síntese química; Carbolinas/farmacologia; Linhagem Celular Tumoral; Técnicas de Química Sintética; Teoria da Densidade Funcional; Compostos Ferrosos/síntese química; Compostos Ferrosos/farmacologia; Humanos; Metalocenos/síntese química; Metalocenos/farmacologia; Modelos Teóricos; Conformação Molecular; Estrutura Molecular; Análise Espectral; Relação Estrutura-Atividade

Palavras-chave

DFT calculations; NMR spectroscopy; X-ray diffraction; conformation; cytotoxic activity; diastereoselectivity; ferrocene; organic synthesis; structure-activity relationships; ß-carboline

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carbolinas / Compostos Ferrosos / Metalocenos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Molecules Assunto da revista: BIOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Hungria

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