Characterization of CD103<sup>+</sup> CD8<sup>+</sup> tissue-resident T cells in esophageal squamous cell carcinoma: may be tumor reactive and resurrected by anti-PD-1 blockade.

Han, Lu; Gao, Quan-Li; Zhou, Xiu-Man; Shi, Chao; Chen, Guan-Yu; Song, Yong-Ping; Yao, Yong-Jie; Zhao, Yu-Miao; Wen, Xue-Yan; Liu, Shi-Lei; Qi, Yuan-Ming; Gao, Yan-Feng

Characterization of CD103⁺ CD8⁺ tissue-resident T cells in esophageal squamous cell carcinoma: may be tumor reactive and resurrected by anti-PD-1 blockade.

Han, Lu; Gao, Quan-Li; Zhou, Xiu-Man; Shi, Chao; Chen, Guan-Yu; Song, Yong-Ping; Yao, Yong-Jie; Zhao, Yu-Miao; Wen, Xue-Yan; Liu, Shi-Lei; Qi, Yuan-Ming; Gao, Yan-Feng.

Afiliação

Han L; School of Life Sciences, Zhengzhou University, Zhengzhou, 450001, China.
Gao QL; Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, 450008, China.
Zhou XM; Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, 450008, China.
Shi C; School of Life Sciences, Zhengzhou University, Zhengzhou, 450001, China.
Chen GY; Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, 450008, China.
Song YP; School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen, 518107, China.
Yao YJ; Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, 450008, China.
Zhao YM; School of Life Sciences, Zhengzhou University, Zhengzhou, 450001, China.
Wen XY; School of Life Sciences, Zhengzhou University, Zhengzhou, 450001, China.
Liu SL; School of Life Sciences, Zhengzhou University, Zhengzhou, 450001, China.
Qi YM; Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, 450008, China.
Gao YF; School of Life Sciences, Zhengzhou University, Zhengzhou, 450001, China.

Cancer Immunol Immunother ; 69(8): 1493-1504, 2020 Aug.

Article em En | MEDLINE | ID: mdl-32285170

Assuntos

Antígenos CD/metabolismo; Linfócitos T CD8-Positivos/imunologia; Neoplasias Esofágicas/imunologia; Neoplasias Esofágicas/metabolismo; Cadeias alfa de Integrinas/metabolismo; Linfócitos do Interstício Tumoral/imunologia; Receptor de Morte Celular Programada 1/antagonistas & inibidores; Microambiente Tumoral/imunologia; 4-Nitroquinolina-1-Óxido/toxicidade; Adulto; Idoso; Animais; Anticorpos Monoclonais/farmacologia; Antígenos CD/imunologia; Biomarcadores Tumorais; Carcinógenos/toxicidade; Estudos de Coortes; Neoplasias Esofágicas/induzido quimicamente; Neoplasias Esofágicas/patologia; Carcinoma de Células Escamosas do Esôfago/induzido quimicamente; Carcinoma de Células Escamosas do Esôfago/imunologia; Carcinoma de Células Escamosas do Esôfago/metabolismo; Carcinoma de Células Escamosas do Esôfago/patologia; Feminino; Seguimentos; Humanos; Cadeias alfa de Integrinas/imunologia; Masculino; Camundongos Endogâmicos C57BL; Pessoa de Meia-Idade; Prognóstico; Receptor de Morte Celular Programada 1/imunologia; Taxa de Sobrevida; Células Tumorais Cultivadas

Palavras-chave

CD103; Esophageal squamous cell carcinoma; Tissue-resident T cells; Tumor-infiltrating lymphocytes

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Esofágicas / Antígenos CD / Linfócitos do Interstício Tumoral / Linfócitos T CD8-Positivos / Cadeias alfa de Integrinas / Microambiente Tumoral / Receptor de Morte Celular Programada 1 Tipo de estudo: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Cancer Immunol Immunother Assunto da revista: ALERGIA E IMUNOLOGIA / NEOPLASIAS / TERAPEUTICA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

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