Chartarlactams Q-T, Dimeric Phenylspirodrimanes with Antibacterial and Antiviral Activities.
Chem Biodivers
; 17(6): e2000170, 2020 Jun.
Article
em En
| MEDLINE
| ID: mdl-32289204
ABSTRACT
Four new phenylspirodrimane-type dimers, namely chartarlactams Q-T, along with stachyin B were isolated from the fermentation broth of a sponge-derived fungus Stachybotrys chartarum WGC-25â
C-6. Chartarlactams Q-T were structurally featured by the dimerization of two units of phenylspirodrimane linked by a C-N bond. Their structures were determined on the basis of extensive spectroscopic analysis, while quantum ECD calculation and modified Mosher's method were used for the assignment of absolute configurations. Chartarlactams Q-S and stachyin B showed moderate inhibition against bacterial pathogen Staphylococcus aureus with MIC values ranging from 4 µg/mL to 16 µg/mL, and chartarlactam T exhibited significant inhibition toward ZIKV virus.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Stachybotrys
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Sesquiterpenos Policíclicos
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Lactamas
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Antibacterianos
Idioma:
En
Revista:
Chem Biodivers
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2020
Tipo de documento:
Article