Synthesis and antitumor evaluation of (aryl)methyl-amine derivatives of dehydroabietic acid-based B ring-fused-thiazole as potential PI3K/AKT/mTOR signaling pathway inhibitors.

Chen, Nai-Yuan; Xie, Yu-Lan; Lu, Guo-Dong; Ye, Fang; Li, Xin-Yu; Huang, Yu-Wen; Huang, Ming-Li; Chen, Tie-Yu; Li, Cui-Ping

Chen, Nai-Yuan; Xie, Yu-Lan; Lu, Guo-Dong; Ye, Fang; Li, Xin-Yu; Huang, Yu-Wen; Huang, Ming-Li; Chen, Tie-Yu; Li, Cui-Ping.

Afiliação

Chen NY; School of Public Health, Guangxi Medical University, Nanning, 530021, China. chennaiyuan@gxmu.edu.cn.
Xie YL; Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning, 530021, China. chennaiyuan@gxmu.edu.cn.
Lu GD; School of Public Health, Guangxi Medical University, Nanning, 530021, China.
Ye F; Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning, 530021, China.
Li XY; School of Public Health, Guangxi Medical University, Nanning, 530021, China.
Huang YW; Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning, 530021, China.
Huang ML; School of Preclinical Medicine, Guangxi Medical University, Nanning, 530021, China.
Chen TY; Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning, 530021, China.
Li CP; School of Preclinical Medicine, Guangxi Medical University, Nanning, 530021, China.

Mol Divers ; 25(2): 967-979, 2021 May.

Article em En | MEDLINE | ID: mdl-32297120

Assuntos

Abietanos; Antineoplásicos; Metilaminas; Inibidores de Fosfoinositídeo-3 Quinase; Inibidores de Proteínas Quinases; Tiazóis; Abietanos/química; Abietanos/farmacologia; Antineoplásicos/química; Antineoplásicos/farmacologia; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Humanos; Metilaminas/química; Metilaminas/farmacologia; Simulação de Acoplamento Molecular; Fosfatidilinositol 3-Quinases/metabolismo; Inibidores de Fosfoinositídeo-3 Quinase/química; Inibidores de Fosfoinositídeo-3 Quinase/farmacologia; Inibidores de Proteínas Quinases/química; Inibidores de Proteínas Quinases/farmacologia; Proteínas Proto-Oncogênicas c-akt/metabolismo; Transdução de Sinais/efeitos dos fármacos; Serina-Treonina Quinases TOR/metabolismo; Tiazóis/química; Tiazóis/farmacologia

Palavras-chave

Activity; Antitumor; Dehydroabietic acid; Synthesis; Thiazole

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tiazóis / Abietanos / Inibidores de Proteínas Quinases / Inibidores de Fosfoinositídeo-3 Quinase / Metilaminas / Antineoplásicos Limite: Humans Idioma: En Revista: Mol Divers Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google