Targeting spinal TRAF6 expression attenuates chronic visceral pain in adult rats with neonatal colonic inflammation.

Weng, Rui-Xia; Chen, Wei; Tang, Jia-Ni; Sun, Qian; Li, Meng; Xu, Xue; Zhang, Ping-An; Zhang, Ying; Hu, Chuang-Ying; Xu, Guang-Yin

Weng, Rui-Xia; Chen, Wei; Tang, Jia-Ni; Sun, Qian; Li, Meng; Xu, Xue; Zhang, Ping-An; Zhang, Ying; Hu, Chuang-Ying; Xu, Guang-Yin.

Afiliação

Weng RX; Jiangsu Key Laboratory of Neuropsychiatric Diseases, Institute of Neuroscience, The Second Affiliated Hospital of Soochow University, Suzhou, P.R. China.
Chen W; People's Hospital of Suzhou National New & Hi-Tech Industrial Development Zone, Suzhou, P.R. China.
Tang JN; Jiangsu Key Laboratory of Neuropsychiatric Diseases, Institute of Neuroscience, The Second Affiliated Hospital of Soochow University, Suzhou, P.R. China.
Sun Q; Jiangsu Key Laboratory of Neuropsychiatric Diseases, Institute of Neuroscience, The Second Affiliated Hospital of Soochow University, Suzhou, P.R. China.
Li M; Jiangsu Key Laboratory of Neuropsychiatric Diseases, Institute of Neuroscience, The Second Affiliated Hospital of Soochow University, Suzhou, P.R. China.
Xu X; People's Hospital of Suzhou National New & Hi-Tech Industrial Development Zone, Suzhou, P.R. China.
Zhang PA; Jiangsu Key Laboratory of Neuropsychiatric Diseases, Institute of Neuroscience, The Second Affiliated Hospital of Soochow University, Suzhou, P.R. China.
Zhang Y; People's Hospital of Suzhou National New & Hi-Tech Industrial Development Zone, Suzhou, P.R. China.
Hu CY; Jiangsu Key Laboratory of Neuropsychiatric Diseases, Institute of Neuroscience, The Second Affiliated Hospital of Soochow University, Suzhou, P.R. China.
Xu GY; Jiangsu Key Laboratory of Neuropsychiatric Diseases, Institute of Neuroscience, The Second Affiliated Hospital of Soochow University, Suzhou, P.R. China.

Mol Pain ; 16: 1744806920918059, 2020.

Article em En | MEDLINE | ID: mdl-32299285

Assuntos

Dor Crônica/tratamento farmacológico; Colo/patologia; Inflamação/terapia; Neuralgia/terapia; Transmissão Sináptica; Fator 6 Associado a Receptor de TNF/metabolismo; Dor Visceral/tratamento farmacológico; Animais; Animais Recém-Nascidos; Colo/metabolismo; Modelos Animais de Doenças; Inflamação/metabolismo; Síndrome do Intestino Irritável/metabolismo; Síndrome do Intestino Irritável/patologia; Masculino; Microscopia de Fluorescência; Neurônios/metabolismo; Técnicas de Patch-Clamp; RNA Interferente Pequeno/metabolismo; Ratos; Ratos Sprague-Dawley; Transdução de Sinais; Medula Espinal/metabolismo; Substância Gelatinosa/metabolismo; Regulação para Cima

Palavras-chave

Irritable bowel syndrome; cystathionine ß synthetase; spinal cord; tumor necrosis factor receptor-associated factor 6; visceral pain

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Colo / Transmissão Sináptica / Fator 6 Associado a Receptor de TNF / Dor Crônica / Dor Visceral / Inflamação / Neuralgia Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Mol Pain Assunto da revista: BIOLOGIA MOLECULAR / NEUROLOGIA / PSICOFISIOLOGIA Ano de publicação: 2020 Tipo de documento: Article

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