High association of MOG-IgG antibodies in children with bilateral optic neuritis.
Eur J Paediatr Neurol
; 27: 86-93, 2020 Jul.
Article
em En
| MEDLINE
| ID: mdl-32327391
ABSTRACT
BACKGROUND:
Bilateral optic neuritis (bilON) is a rare clinical presentation often thought to be associated with relapsing disorders such as neuromyelitis optica spectrum disorders (NMOSD) or multiple sclerosis (MS).OBJECTIVE:
To characterize the clinical, radiological phenotype and antibody status of children presenting with bilON. MATERIAL ANDMETHODS:
Retrospective multicenter study on children with bilON age <18 years with a first episode aquired demyelinating syndrome (ADS), cMRI, AQP4- and serum MOG-antibody status and follow-up data were collected.RESULTS:
30 patients (fm = 1515, median age 8.0y) with bilON met the inclusion criteria. 22/30 (73%) were MOG-positive (median 11280, range 1160-11520). No patient showed AQP4-abs. 4/30 patients (13%), all with high MOG-abs titers, had recurrent episodes. No patient developed MS. Improvement after IVMP was observed in most patients (26/30; 87%). Outcome was favorable with no sequelae in 22/30 patients. Serial MOG-abs titers tested in 15/22 patients decreased to a median of 1160 (range 0-1640) over a period of 31 months (range 2-141 months) in 14/15 (93%) patients. MR imaging showed a predominantly anterior affection of the visual system in seropositive patients with bilateral intraorbital lesions in 68% (15/22), compared to 25% in MOG-negative patients (2/8).CONCLUSION:
Pediatric bilON is associated with high MOG-abs titers in combination with anterior involvement of the visual system. Despite severe loss of vision, the majority of patients shows distinct recovery after IVMP.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autoanticorpos
/
Neurite Óptica
/
Proteína ran de Ligação ao GTP
Tipo de estudo:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Male
Idioma:
En
Revista:
Eur J Paediatr Neurol
Assunto da revista:
NEUROLOGIA
/
PEDIATRIA
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Alemanha