USP8 protects against lipopolysaccharide-induced cognitive and motor deficits by modulating microglia phenotypes through TLR4/MyD88/NF-&#954;B signaling pathway in mice.

Zhao, JiaYi; Bi, Wei; Zhang, JiaWei; Xiao, Shu; Zhou, RuiYi; Tsang, Chi Kwan; Lu, DaXiang; Zhu, Lihong

USP8 protects against lipopolysaccharide-induced cognitive and motor deficits by modulating microglia phenotypes through TLR4/MyD88/NF-κB signaling pathway in mice.

Zhao, JiaYi; Bi, Wei; Zhang, JiaWei; Xiao, Shu; Zhou, RuiYi; Tsang, Chi Kwan; Lu, DaXiang; Zhu, Lihong.

Afiliação

Zhao J; Department of Pathophysiology, School of Medicine, Jinan University, Guangzhou, Guangdong Province 510632, China.
Bi W; Department of Neurology, The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong Province 510630, China.
Zhang J; Department of Pathophysiology, School of Medicine, Jinan University, Guangzhou, Guangdong Province 510632, China.
Xiao S; Department of Pathophysiology, School of Medicine, Jinan University, Guangzhou, Guangdong Province 510632, China.
Zhou R; Department of Neurology, The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong Province 510630, China.
Tsang CK; Clinical Neuoscience Institute, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong Province 510630, China.
Lu D; Department of Pathophysiology, School of Medicine, Jinan University, Guangzhou, Guangdong Province 510632, China.
Zhu L; Department of Pathophysiology, School of Medicine, Jinan University, Guangzhou, Guangdong Province 510632, China. Electronic address: lhzhu@jnu.edu.cn.

Brain Behav Immun ; 88: 582-596, 2020 08.

Article em En | MEDLINE | ID: mdl-32335193

Assuntos

Cognição; Transdução de Sinais; Animais; Endopeptidases; Complexos Endossomais de Distribuição Requeridos para Transporte; Lipopolissacarídeos; Camundongos; Microglia/metabolismo; Fator 88 de Diferenciação Mieloide/metabolismo; NF-kappa B/metabolismo; Óxido Nítrico/metabolismo; Óxido Nítrico Sintase Tipo II/metabolismo; Fenótipo; Receptor 4 Toll-Like/metabolismo; Ubiquitina Tiolesterase

Palavras-chave

Cognitive impairment; Microglia phenotypes; Motor impairment; Neurodegenerative diseases; Neuroinflammation; Ubiquitin-specific protease 8 (USP8); lipopolysaccharide (LPS)

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Cognição Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Brain Behav Immun Assunto da revista: ALERGIA E IMUNOLOGIA / CEREBRO / PSICOFISIOLOGIA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google