The effect of computed tomography on oxidative stress level and some antioxidant parameters.
Acta Radiol
; 62(2): 260-265, 2021 Feb.
Article
em En
| MEDLINE
| ID: mdl-32397734
ABSTRACT
BACKGROUND:
X-rays are defined as ionizing radiation and hydrolyze the water, causing free radical formation. Oxidative stress is the damage that occurs in cells due to the lack of antioxidants, which detoxifies them, with the increased production of free radicals that occur during normal cellular metabolism.PURPOSE:
To examine the acute effects of computed tomography (CT), i.e. ionizing radiation, on oxidative stress and antioxidant defense mechanisms. MATERIAL ANDMETHODS:
The study included a total of 53 patients that were selected among the patients that underwent non-contrast full-body CT. Malondialdehyde (MDA) and reduced glutathione (GSH) levels and superoxide dismutase (SOD) and catalase (CAT) activities were investigated in blood samples taken from patients.RESULTS:
The post-scan levels of MDA increased significantly while the post-scan levels of GSH, SOD, and CAT decreased significantly compared to their pre-scan levels.CONCLUSION:
CT, which is a widely used X-ray imaging technique and has numerous known side effects, was found to increase the levels of MDA, which is an indicator of oxidative stress, and to decrease the levels of some antioxidants including GSH, SOD, and CAT.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Superóxido Dismutase
/
Tomografia Computadorizada por Raios X
/
Estresse Oxidativo
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Glutationa
/
Malondialdeído
/
Antioxidantes
Tipo de estudo:
Observational_studies
Limite:
Adult
/
Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Acta Radiol
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Turquia