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The anti-cancer drug ABTL0812 induces ER stress-mediated cytotoxic autophagy by increasing dihydroceramide levels in cancer cells.
Muñoz-Guardiola, Pau; Casas, Josefina; Megías-Roda, Elisabet; Solé, Sònia; Perez-Montoyo, Héctor; Yeste-Velasco, Marc; Erazo, Tatiana; Diéguez-Martínez, Nora; Espinosa-Gil, Sergio; Muñoz-Pinedo, Cristina; Yoldi, Guillermo; Abad, Jose L; Segura, Miguel F; Moran, Teresa; Romeo, Margarita; Bosch-Barrera, Joaquim; Oaknin, Ana; Alfón, Jose; Domènech, Carles; Fabriàs, Gemma; Velasco, Guillermo; Lizcano, Jose M.
Afiliação
  • Muñoz-Guardiola P; Protein Kinases and Signal Transduction Laboratory, Departament De Bioquímica I Biologia Molecular and Institut De Neurociències, Universitat Autònoma De Barcelona (UAB), Barcelona, Spain.
  • Casas J; Ability Pharmaceuticals, SL, Cerdanyola Del Vallès, Barcelona, Spain.
  • Megías-Roda E; Research Unit on BioActive Molecules (RUBAM), Department of Biological Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Jordi Girona, Barcelona, Spain; Liver and Digestive Diseases Networking Biomedical Research Centre (CIBEREHD) ISCII, Madrid, Spain.
  • Solé S; Protein Kinases and Signal Transduction Laboratory, Departament De Bioquímica I Biologia Molecular and Institut De Neurociències, Universitat Autònoma De Barcelona (UAB), Barcelona, Spain.
  • Perez-Montoyo H; Ability Pharmaceuticals, SL, Cerdanyola Del Vallès, Barcelona, Spain.
  • Yeste-Velasco M; Ability Pharmaceuticals, SL, Cerdanyola Del Vallès, Barcelona, Spain.
  • Erazo T; Ability Pharmaceuticals, SL, Cerdanyola Del Vallès, Barcelona, Spain.
  • Diéguez-Martínez N; Ability Pharmaceuticals, SL, Cerdanyola Del Vallès, Barcelona, Spain.
  • Espinosa-Gil S; Protein Kinases and Signal Transduction Laboratory, Departament De Bioquímica I Biologia Molecular and Institut De Neurociències, Universitat Autònoma De Barcelona (UAB), Barcelona, Spain.
  • Muñoz-Pinedo C; Protein Kinases and Signal Transduction Laboratory, Departament De Bioquímica I Biologia Molecular and Institut De Neurociències, Universitat Autònoma De Barcelona (UAB), Barcelona, Spain.
  • Yoldi G; Protein Kinases and Signal Transduction Laboratory, Departament De Bioquímica I Biologia Molecular and Institut De Neurociències, Universitat Autònoma De Barcelona (UAB), Barcelona, Spain.
  • Abad JL; Cell Death and Metabolism Group, Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.
  • Segura MF; Protein Kinases and Signal Transduction Laboratory, Departament De Bioquímica I Biologia Molecular and Institut De Neurociències, Universitat Autònoma De Barcelona (UAB), Barcelona, Spain.
  • Moran T; Research Unit on BioActive Molecules (RUBAM), Department of Biological Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Jordi Girona, Barcelona, Spain; Liver and Digestive Diseases Networking Biomedical Research Centre (CIBEREHD) ISCII, Madrid, Spain.
  • Romeo M; Group of Translational Research in Child and Adolescent Cancer, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma De Barcelona (UAB), Barcelona, Spain.
  • Bosch-Barrera J; Medical Oncology Department, Catalan Institute of Oncology, Hospital Germans Trias I Pujol, Universitat Autònoma de Barcelona, Applied Research Group in Oncology (B-ARGO), Badalona, Spain.
  • Oaknin A; Medical Oncology Department, Catalan Institute of Oncology, Hospital Germans Trias I Pujol, Universitat Autònoma de Barcelona, Applied Research Group in Oncology (B-ARGO), Badalona, Spain.
  • Alfón J; Department of Medical Oncology, Catalan Institute of Oncology (ICO), Dr. Josep Trueta University Hospital and Girona Biomedical Research Institute (IDIBGI), Girona, Spain.
  • Domènech C; Medical Oncology Department, Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.
  • Fabriàs G; Ability Pharmaceuticals, SL, Cerdanyola Del Vallès, Barcelona, Spain.
  • Velasco G; Ability Pharmaceuticals, SL, Cerdanyola Del Vallès, Barcelona, Spain.
  • Lizcano JM; Research Unit on BioActive Molecules (RUBAM), Department of Biological Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Jordi Girona, Barcelona, Spain; Liver and Digestive Diseases Networking Biomedical Research Centre (CIBEREHD) ISCII, Madrid, Spain.
Autophagy ; 17(6): 1349-1366, 2021 06.
Article em En | MEDLINE | ID: mdl-32397857
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autofagia / Ácidos Linoleicos / Carcinoma Pulmonar de Células não Pequenas / Fibroblastos Limite: Humans Idioma: En Revista: Autophagy Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Espanha
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Autofagia / Ácidos Linoleicos / Carcinoma Pulmonar de Células não Pequenas / Fibroblastos Limite: Humans Idioma: En Revista: Autophagy Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Espanha