L-glutamine as a T2 exchange contrast agent.
Magn Reson Med
; 84(4): 2055-2062, 2020 10.
Article
em En
| MEDLINE
| ID: mdl-32406063
ABSTRACT
PURPOSE:
The potential of L-glutamine as a T2 exchange contrast agent in MRI was investigated.METHODS:
The T2 relaxation rate of L-glutamine solutions prepared in various concentrations was measured at 9.4 T. A series of T2 -weighted images in a mouse cancer model was acquired with an L-glutamine solution infusion.RESULTS:
The T2 relaxivity caused by the exchange (R2ex ) at 37°C was 0.069 s-1 mM-1 and 0.102 s-1 mM-1 for glutamine and glutamate solutions at pH = 7.2, respectively. The R2ex of glutamine at pH = 6.1-6.7 was in the 0.097-0.1 s-1 mM-1 range. No significant dependence of T1 on the concentration of glutamine was observed. The dynamic measurement of T2 -weighted images in vivo showed that the glutamine uptake was primarily observed at the localized part of the tumorCONCLUSION:
L-glutamine can be used as a T2 exchange contrast agent and images of glutamine uptake in vivo can be acquired.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Meios de Contraste
/
Glutamina
Limite:
Animals
Idioma:
En
Revista:
Magn Reson Med
Assunto da revista:
DIAGNOSTICO POR IMAGEM
Ano de publicação:
2020
Tipo de documento:
Article