Trends in Distribution and Antibiotic Resistance of Bacteria Isolated from Urine Cultures of Children in Northern Israel Between 2010 and 2017.
Microb Drug Resist
; 26(11): 1342-1349, 2020 Nov.
Article
em En
| MEDLINE
| ID: mdl-32407193
ABSTRACT
Objectives:
To identify the changing trends of uropathogens over the years 2010-2017 and examine the incidence of both antibiotic resistance and extended spectrum beta lactamases (ESBL)-producing Enterobacteriaceae in urine cultures from pediatric patients. StudyDesign:
Electronic medical records of 1,056 children, admitted to the Poriya Medical Center in Israel, between 2010 and 2017 with positive urine cultures, were reviewed for bacterial species and antibiotics resistance.Results:
The leading pathogen was Escherichia coli (76%), followed by Klebsiella (7%), Enterococcus (5.8%), and Proteus (4%). Statistically significant gender-specific and ethnicity-specific differences in the distribution of uropathogens were found. E. coli was more common in females compared to males. Escherichia coli constituted most (92.3%) of the ESBL-positive cultures, while only 4.6% isolates carried Klebsiella, 1.5% carried Enterobacter spp., and 1.5% carried Morganella. Prevalence of ESBL-producing E. coli increased throughout the study period. Increasing prevalence over time was noted for ceftriaxone, cefuroxime, amoxicillin/clavulanate, and ampicillin resistance.Conclusions:
Gender and ethnic background should be taken into consideration when choosing empiric antibiotic therapy for urinary tract infections in children. Similarly, the continuous increase in resistance to cefuroxime and amoxicillin/clavulanate should be considered when prescribing therapy in Israel. Ceftriaxone and gentamicin are still the antibiotics of choice for inpatient parenteral empiric treatment.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções Urinárias
/
Urina
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Resistência Microbiana a Medicamentos
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Enterobacteriaceae
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Infecções por Enterobacteriaceae
Tipo de estudo:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Adolescent
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Child
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Child, preschool
/
Female
/
Humans
/
Infant
/
Male
/
Newborn
País/Região como assunto:
Asia
Idioma:
En
Revista:
Microb Drug Resist
Assunto da revista:
MICROBIOLOGIA
/
TERAPIA POR MEDICAMENTOS
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Israel